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AuthorAlalwani, Joud
AuthorEljazzar, sereen
AuthorBasil, Maya
AuthorTayyem, Reema
Available date2022-04-11T08:55:19Z
Publication Date2022-04-09
Publication NameClinical Obesity
Identifierhttp://dx.doi.org/10.1111/cob.12525
CitationAlalwani J, Eljazzar S, Basil M, Tayyem R. The impact of health status, diet and lifestyle on non-alcoholic fatty liver disease: Narrative review. Clinical Obesity. 2022;e12525. doi:10.1111/cob.12525
ISSN1758-8103
URIhttp://hdl.handle.net/10576/29526
AbstractNon-alcoholic fatty liver disease (NAFLD) is defined as the abnormal accumulation of triglycerides in the liver. NAFLD has a global prevalence of almost 30%, while incidence is rising with increasing levels of obesity, type 2 diabetes mellitus (T2DM) and metabolic syndrome. Nutrition plays a significant role in both the prevention and treatment of NAFLD. Therefore, the aim of this literature review is to explore the associations between dietary, lifestyle and other risk factors and the risk for developing NAFLD. Dietary patterns, lifestyle behaviours, comorbidities, or a combination of any may contribute to either the progression or prevention of NAFLD. Having diabetes, hypertension, or having obesity might increase the progression of NAFLD if not well treated and controlled. Diet influences the progression of NAFLD; following a western diet or simply a high-fat diet may contribute to the worsening of NAFLD and further progression to non-alcoholic steatohepatitis (NASH) and cirrhosis in later stages. On the other hand, the Mediterranean diet is the gold standard for both the treatment and prevention of NAFLD. Social behaviours, such as smoking, caffeine consumption and physical activity also play a role in the pathophysiology of NAFLD. Nutrition contributes significantly to the prevention or treatment of NAFLD, since this disease can be managed by diet and physical activity. However, further studies are still needed for a better understanding of the mechanisms of action. Randomized control trials are also needed to confirm findings in observational studies.
Languageen
PublisherWiley
Subjectbody mass index
cardiovascular disease
diabetes type 2
dietary patterns
insulin resistance
lifestyle
non-alcoholic fatty liver
nutrition
obesity
TitleThe impact of health status, diet and lifestyle on non-alcoholic fatty liver disease: Narrative review
TypeArticle Review
ESSN1758-8111


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