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AuthorMarouf, Nadya
AuthorCai, Wenji
AuthorSaid, Khalid N.
AuthorDaas, Hanin
AuthorDiab, Hanan
AuthorChinta, Venkateswara Rao
AuthorHssain, Ali Ait
AuthorNicolau, Belinda
AuthorSanz, Mariano
AuthorTamimi, Faleh
Available date2022-05-15T07:57:10Z
Publication Date2021-04-01
Publication NameJournal of Clinical Periodontology
Identifierhttp://dx.doi.org/10.1111/jcpe.13435
CitationMarouf, N., Cai, W., Said, K.N., Daas, H., Diab, H., Chinta, V.R., Hssain, A.A., Nicolau, B., Sanz, M. and Tamimi, F. (2021), Association between periodontitis and severity of COVID-19 infection: A case–control study. J Clin Periodontol, 48: 483-491. https://doi.org/10.1111/jcpe.13435
ISSN03036979
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85101428748&origin=inward
URIhttp://hdl.handle.net/10576/30872
AbstractAim: COVID-19 is associated with an exacerbated inflammatory response that can result in fatal outcomes. Systemic inflammation is also a main characteristic of periodontitis. Therefore, we investigated the association of periodontitis with COVID-19 complications. Materials and Methods: A case–control study was performed using the national electronic health records of the State of Qatar between February and July 2020. Cases were defined as patients who suffered COVID-19 complications (death, ICU admissions or assisted ventilation), and controls were COVID-19 patients discharged without major complications. Periodontal conditions were assessed using dental radiographs from the same database. Associations between periodontitis and COVID 19 complications were analysed using logistic regression models adjusted for demographic, medical and behaviour factors. Results: In total, 568 patients were included. After adjusting for potential confounders, periodontitis was associated with COVID-19 complication including death (OR = 8.81, 95% CI 1.00–77.7), ICU admission (OR = 3.54, 95% CI 1.39–9.05) and need for assisted ventilation (OR = 4.57, 95% CI 1.19–17.4). Similarly, blood levels of white blood cells, D-dimer and C Reactive Protein were significantly higher in COVID-19 patients with periodontitis. Conclusion: Periodontitis was associated with higher risk of ICU admission, need for assisted ventilation and death of COVID-19 patients, and with increased blood levels of biomarkers linked to worse disease outcomes.
Languageen
PublisherWiley
SubjectCovid-19
death
ICU admissions
periodontitis
ventilation
TitleAssociation between periodontitis and severity of COVID-19 infection: A case–control study
TypeArticle
Issue Number4
Volume Number48
ESSN1600-051X
dc.accessType Open Access


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