Browsing Master in Pharmacy by Title
Now showing items 39-58 of 58
-
Medication-Related Burden among Patients with Chronic Disease Conditions: Perspectives of Patients attending Non-Communicable Disease Clinics in a Primary Healthcare Setting in Qatar
(2017 , Master Thesis)This study aimed to adapt a medication-related burden instrument, the Living with Medicines Questionnaire (LMQ), into the Arabic context, report the psychometric properties of the Arabic version, and assess the burden ... -
MODULATION OF THE MOLECULAR EXPRESSION AND FUNCTION OF BCL-2 FAMILY PROTEINS BY THE ARYL HYDROCARBON RECEPTOR IN BREAST CANCER STEM CELLS OF THE MDA-MB-231
(2021 , Master Thesis)Breast cancer (BC) is a frequently occurring neoplasm in women and is a second major cause of cancer related deaths. Despite the remarkable advancements in the understanding of BC and its treatments, the diseases still ... -
MOLECULAR FEATURES OF TRIPLE NEGATIVE BREAST CANCER STEM CELLS: A GENE EXPRESSION PROFILING ANALYSIS OF MDA-MB-231 CELLS
(2021 , Master Thesis)Triple negative breast cancer (TNBC) is a chemoresistant subtype of female breast tumors. Chemoresistance is attributed to the presence of long-lived cancer stem cells (CSCs) responsible for therapy failure. This study ... -
Multi-Criteria Decision Analytic Model for the Comparative Formulary Inclusion of Direct Oral Anticoagulant in Qatar
(2020 , Master Thesis)Aim: The formulary inclusion of direct oral anticoagulant (DOACs) in the government hospital health services in Qatar is not comparative or restricted. Requests to include a DOAC in the formulary are typically accepted ... -
Nano Liposomal Formulation for A Novel Chalcone Compound as A Potential Anticancer Delivery System for Triple-Negative Breast Cancer
(2024 , Master Thesis)Triple negative breast cancer is the most aggressive type of breast malignancy accounting for 15-20% of all breast cancer cases. Treatment of TNBC remains limited, with a high risk of relapse and metastasis to other organs. ... -
Pharmacoeconomics Evaluation of the Systemic Antifungal Posaconazole for Prophylaxis against Invasive Fungal Infections among Immunocompromised Cancer Patients in Qatar
(2018 , Master Thesis)The immunocompromised hematologic malignancy patients, at the National Center for Cancer Care (NCCCR) in Qatar, receive the antifungal posaconazole for prophylaxis as systemic prophylaxis against invasive fungal infections ... -
PRODUCTION OF LETROZOLE-LOADED MONODISPERSE POLYMERIC-BASED MICROPARTICLES FOR BREAST CANCER THERAPY
(2017 , Master Thesis)Letrozole (LTZ) is effective for the treatment of hormone-receptor-positive breast cancer in postmenopausal women. However, due to its adverse effects this study was designed to investigate the feasibility of producing ... -
PROTECTIVE EFFECTS OF METFORMIN IN AN IN VITRO MODEL OF PROTEINURIC KIDNEY DISEASE
(2017 , Master Thesis)Albuminuria, a hallmark of chronic kidney disease (CKD), plays a crucial role in the etiology of CKD. High albumin levels are thought to induce endoplasmic reticulum (ER) stress and activate the AKT pathway, and lead to ... -
Relationship between the Stages of Change and Medication Adherence in Patients with Type 2 Diabetes Mellitus in a Primary Health Care Setting in Qatar
(2016 , Master Thesis)Background: Non-adherence to medications is a major concern among patients with type 2 diabetes mellitus (T2DM). Failure to achieve positive health-related outcomes could be associated with non-adherence. Medication ... -
THE ROLE OF P90 RIBOSOMAL S6 KINASE AND AUTOPHAGY IN SUNITINIB AND PONATINIB-INDUCED CARDIOTOXICITY
(2019 , Master Thesis)In recent years, the paradigm cancer management has shifted towards a targeted approach. Among the newly targeted anticancer therapies are ponatinib and sunitinib, small molecules tyrosine kinase inhibitors (TKIs), used ... -
Sleep Patterns among University Students and Insomnia Management in Primary Care Settings in Qatar: A Two-Phase Investigation
(2020 , Master Thesis)Insomnia is a public health concern that affects approximately a third of adult population worldwide. The aim of this research was to investigate insomnia and its management among university students and primary care ... -
STANDARDIZATION OF AN IN VITRO MODEL OF DIABETIC NEPHROPATHY IN RENAL TUBULAR CELLS AND INVESTIGATION OF THE ROLE OF ALDOSE REDUCTASE PATHWAY IN HIGH GLUCOSE-INDUCED RENAL CELL INJURY
(2015 , Master Thesis)Diabetic nephropathy (DN) is the leading cause of end stage renal disease, and one of the most serious microvascular complications of diabetes mellitus. Increase in the shift of glucose into the aldose reductase pathway ... -
Strengthening the Quality of Clinical Pharmacokinetic Studies: Development and Validation of a Critical Appraisal Tool For Clinical Pharmacokinetic Research
(2020 , Master Thesis)Background: Critical appraisal process is central to the practice of evidence-based medicine that aids in assessing the quality of the published scientific knowledge. To our knowledge, there is no critical appraisal ... -
SUCCINYLATED CURCUMIN LOADED IN MANNOSYLATED CHITOSAN NANOPARTICLES FOR COLON CANCER THERAPY
(06-2 , Master Thesis)Colon cancer (CRC) is the second leading cause of death and the third most diagnosed type worldwide. Although curcumin (CUR) has potent anticancer activity, it suffers from low solubility, bioavailability, and instability. ... -
Surface Coating of Carbon Nanofiber by Mesoporous Silica: a Promising Strategy to Reduce its Toxicity during Embryogenesis
(2021 , Master Thesis)Although carbon nanofibers (CNFs) have been implicated in biomedical applications, they are still considered as a potential hazard. Conversely, mesoporous silica nanoparticles are generally considered as a suitable and ... -
Synthesis and Pharmacological Evaluation of Different Piperine Analogs for Therapeutic Potential to Prevent ER Stress
(2015 , Master Thesis)Background: Endoplasmic reticulum (ER) is the chief organelle involved in protein folding and maturation. Emerging studies implicate the role of ER stress in the development of chronic kidney disease (CKD). Thus, there is ... -
SYNTHESIS, CHARACTERIZATION AND CYTOCOMPATIBILITY OF HIGHLY POROUS, THREE DIMENSIONAL POLY (1, 10 DECANEDIOL CO-TRICARBALLYLATE) BASED SCAFFOLDS FOR CARDIAC & OTHER TISSUE ENGINEERING APPLICATIONS
(2016 , Master Thesis)Electrospinning is one of the recently developed methods that produces scaffolds resembling the natural extracellular matrix. It can utilize a wide array of natural and synthetic polymer materials to produce three dimensional, ... -
THE EFFECT OF NATURAL AND SYNTHETIC COMPOUNDS ON COLORECTAL CANCER: IN VITRO AND IN VIVO STUDIES
(06-2 , Master Thesis)Colorectal cancer (CRC) is one of the deadliest malignancies in the world. Despite improved treatment, CRC incidence and mortality rates have been increasing lately. Current conventional therapies are associated with severe ... -
THE EFFECT OF OBESITY ON RIVAROXABAN PHARMACOKINETICS AND PHARMACODYNAMICS
(2024 , Dissertation)Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a prevalent condition that is associated with high rates of morbidity and mortality worldwide. Similarly, atrial fibrillation ... -
Trends and Appropriateness of Sodium-glucose Co-transporter 2 Inhibitors Use in Qatar
(2023 , Master Thesis)Background: Sodium glucose co-transporter 2 inhibitors (SGLT2is) are the most recently approved class of oral antidiabetic drugs (ADDs). The objective of this study was to explore the trends in the use of SGLT2is compared ...