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PROTECTIVE EFFECTS OF METFORMIN IN AN IN VITRO MODEL OF PROTEINURIC KIDNEY DISEASE
(Pharmacy, 2017 , Master Thesis)
Albuminuria, a hallmark of chronic kidney disease (CKD), plays a crucial role in the etiology of CKD. High albumin levels are thought to induce endoplasmic reticulum (ER) stress and activate the AKT pathway, and lead to ...
Cathepsin B Induced Cardiomyocyte Hypertrophy Requires Activation of The Na+/H+ Exchanger Isoform-1
(Pharmacy, 2016 , Master Thesis)
Multiple studies have demonstrated that proteases, specifically cathepsin B (Cat B) and matrix metalloproteinase-9 (MMP-9) contribute to the remodeling of the extracellular matrix (ECM), a hallmark of cardiac hypertrophy ...