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SUCCINYLATED CURCUMIN LOADED IN MANNOSYLATED CHITOSAN NANOPARTICLES FOR COLON CANCER THERAPY
(Pharmacy, 06-2 , Master Thesis)
Colon cancer (CRC) is the second leading cause of death and the third most diagnosed type worldwide. Although curcumin (CUR) has potent anticancer activity, it suffers from low solubility, bioavailability, and instability. ...
THE EFFECT OF NATURAL AND SYNTHETIC COMPOUNDS ON COLORECTAL CANCER: IN VITRO AND IN VIVO STUDIES
(Pharmacy, 06-2 , Master Thesis)
Colorectal cancer (CRC) is one of the deadliest malignancies in the world. Despite improved treatment, CRC incidence and mortality rates have been increasing lately. Current conventional therapies are associated with severe ...
ANTICANCER EFFECTS OF MODIFIED CITRUS PECTIN AND CURCUMIN IN CHITOSAN NANOPARTICLES ON COLON CANCER
(Pharmacy, 06-2 , Master Thesis)
We aimed to study the influence of stirring effect while modifying citrus pectin
(CP), in addition to create a combination of curcumin in chitosan-modified citrus pectin
(CCM-NPs) nanoparticles, along with Galectin-3 in ...
Anticancer Activity of Neosetophomone-B, a Fungal Secondary Metabolite, Against Hematological Malignancies
(Pharmacy, 2023 , Dissertation)
Anticancer Activity of Neosetophomone-B, a Fungal Secondary Metabolite, Against Hematological Malignancies downregulation, and p21 and p27 upregulation were observed in NSP-B-treated leukemia, lymphoma, and myeloma cells. ...
Ethanol-Based Proliposomes Incorporating Dexamethasone for The Treatment of COVID-19 Acute Respiratory Distress Syndrome (ARDS) Using Medical Nebulizers
(Pharmacy, 2023 , Master Thesis)
Background/Objective: Systemic dexamethasone has demonstrated mortality
reduction in COVID-19-related acute respiratory distress syndrome (ARDS). The aim
of this study is to use ethanol-based proliposome technology to ...
Cost-effectiveness Analysis of Ibuprofen versus Indomethacin or Paracetamol for the Treatment of Patent Ductus Arteriosus in Preterm Neonates
(Pharmacy, 2021 , Master Thesis)
Objective: This thesis sought to evaluate the cost-effectiveness of oral paracetamol and intravenous (IV) indomethacin as alternatives to ibuprofen for patent ductus arteriosus (PDA) in neonates in Hamad Medical Corporation ...
CLINICAL AND PHARMACOECONOMIC ANALYSES OF CDK4/6 INHIBITORS USE IN STAGE IV BREAST CANCER FEMALES IN THE STATE OF QATAR: A COMPARATIVE RETROSPECTIVE OBSERVATIONAL STUDY WITH COST-EFFECTIVENESS AND COST-UTILITY ANALYSES
(Pharmacy, 2021 , Master Thesis)
Introduction: Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are indicated in the first-line treatment of hormonal receptor positive and HER-2 negative (HR+/HER2- negative) advanced breast cancer. Although phase III ...
MOLECULAR FEATURES OF TRIPLE NEGATIVE BREAST CANCER STEM CELLS: A GENE EXPRESSION PROFILING ANALYSIS OF MDA-MB-231 CELLS
(Pharmacy, 2021 , Master Thesis)
Triple negative breast cancer (TNBC) is a chemoresistant subtype of female breast tumors. Chemoresistance is attributed to the presence of long-lived cancer stem cells (CSCs) responsible for therapy failure. This study ...
MODULATION OF THE MOLECULAR EXPRESSION AND FUNCTION OF BCL-2 FAMILY PROTEINS BY THE ARYL HYDROCARBON RECEPTOR IN BREAST CANCER STEM CELLS OF THE MDA-MB-231
(Pharmacy, 2021 , Master Thesis)
Breast cancer (BC) is a frequently occurring neoplasm in women and is a second major cause of cancer related deaths. Despite the remarkable advancements in the understanding of BC and its treatments, the diseases still ...
COMMUNITY PHARMACISTS' SELF-PERCEIVED COMPETENCY, AND ENABLERS, AND BARRIERS TOWARDS THE MANAGEMENT OF COMMON MINOR AILMENTS IN QATAR
(Pharmacy, 2021 , Master Thesis)
The study aimed to assess community pharmacists' self-perceived competency, and enablers and barriers towards managing common minor ailments in Qatar, and its predictors. A cross-sectional study, with pretested questionnaires, ...