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المؤلفAhmed U.
المؤلفAhmed R.
المؤلفMasoud M.S.
المؤلفTariq M.
المؤلفAshfaq U.A.
المؤلفAugustine R.
المؤلفHasan, Anwarul
تاريخ الإتاحة2022-05-21T10:18:26Z
تاريخ النشر2021
اسم المنشورBiomedical Materials (Bristol)
المصدرScopus
المعرّفhttp://dx.doi.org/10.1088/1748-605X/abe6d8
معرّف المصادر الموحدhttp://hdl.handle.net/10576/31266
الملخصAdvanced biomaterials are increasingly used for numerous medical applications from the delivery of cancer-targeted therapeutics to the treatment of cardiovascular diseases. The issues of foreign body reactions induced by biomaterials must be controlled for preventing treatment failure. Therefore, it is important to assess the biocompatibility and cytotoxicity of biomaterials on cell culture systems before proceeding to in vivo studies in animal models and subsequent clinical trials. Direct use of biomaterials on animals create technical challenges and ethical issues and therefore, the use of non-animal models such as stem cell cultures could be useful for determination of their safety. However, failure to recapitulate the complex in vivo microenvironment have largely restricted stem cell cultures for testing the cytotoxicity of biomaterials. Nevertheless, properties of stem cells such as their self-renewal and ability to differentiate into various cell lineages make them an ideal candidate for in vitro screening studies. Furthermore, the application of stem cells in biomaterials screening studies may overcome the challenges associated with the inability to develop a complex heterogeneous tissue using primary cells. Currently, embryonic stem cells, adult stem cells, and induced pluripotent stem cells are being used as in vitro preliminary biomaterials testing models with demonstrated advantages over mature primary cell or cell line based in vitro models. This review discusses the status and future directions of in vitro stem cell-based cultures and their derivatives such as spheroids and organoids for the screening of their safety before their application to animal models and human in translational research.
اللغةen
الناشرIOP Publishing Ltd
الموضوع2D and 3D stem cell cultures
biocompatibility
biomaterials
cytotoxicity
stem cell models
العنوانStem cells based in vitro models: Trends and prospects in biomaterials cytotoxicity studies
النوعArticle
رقم العدد4
رقم المجلد16
dc.accessType Abstract Only


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