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المؤلفAslam Khan M.U.
المؤلفAl-Arjan W.S.
المؤلفBinkadem M.S.
المؤلفMehboob H.
المؤلفHaider A.
المؤلفRaza M.A.
المؤلفAbd Razak S.I.
المؤلفHasan, Anwarul
المؤلفAmin R.
تاريخ الإتاحة2022-05-21T10:18:27Z
تاريخ النشر2021
اسم المنشورNanomaterials
المصدرScopus
المعرّفhttp://dx.doi.org/10.3390/nano11051319
معرّف المصادر الموحدhttp://hdl.handle.net/10576/31271
الملخصBone tissue engineering is an advanced field for treatment of fractured bones to re-store/regulate biological functions. Biopolymeric/bioceramic-based hybrid nanocomposite scaffolds are potential biomaterials for bone tissue because of biodegradable and biocompatible character-istics. We report synthesis of nanocomposite based on acrylic acid (AAc)/guar gum (GG), nano-hydroxyapatite (HAp NPs), titanium nanoparticles (TiO2 NPs), and optimum graphene oxide (GO) amount via free radical polymerization method. Porous scaffolds were fabricated through freeze-drying technique and coated with silver sulphadiazine. Different techniques were used to investigate functional group, crystal structural properties, morphology/elemental properties, porosity, and mechanical properties of fabricated scaffolds. Results show that increasing amount of TiO2 in combination with optimized GO has improved physicochemical and microstructural properties, mechanical properties (compressive strength (2.96 to 13.31 MPa) and Young?s modulus (39.56 to 300.81 MPa)), and porous properties (pore size (256.11 to 107.42 �m) and porosity (79.97 to 44.32%)). After 150 min, silver sulfadiazine release was found to be ~94.1%. In vitro assay of scaffolds also exhibited promising results against mouse pre-osteoblast (MC3T3-E1) cell lines. Hence, these fabricated scaffolds would be potential biomaterials for bone tissue engineering in biomedical engineering.
اللغةen
الناشرMDPI AG
الموضوعBiocompatibility
Biodegradation
Cytotoxicity
Drug delivery
Graphene oxide
Hybrid scaffolds
Nanocomposite
Tissue engineering
العنوانDevelopment of biopolymeric hybrid scaffold-based on aac/go/nhap/tio2 nanocomposite for bone tissue engineering: In-vitro analysis
النوعArticle
رقم العدد5
رقم المجلد11


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