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AuthorMeng F.
AuthorHasan, Anwarul
AuthorMahdi Nejadi Babadaei M.
AuthorHashemi Kani P.
AuthorJouya Talaei A.
AuthorSharifi M.
AuthorCai T.
AuthorFalahati M.
AuthorCai Y.
Available date2022-05-21T10:18:29Z
Publication Date2020
Publication NameJournal of Advanced Research
ResourceScopus
Identifierhttp://dx.doi.org/10.1016/j.jare.2020.07.017
URIhttp://hdl.handle.net/10576/31295
AbstractBackground: Microscopic patches as quite promising platforms in transdermal drug delivery suffer from conventional injections. In other hand, a wide range of pharmacokinetics, ranging from fast oral administration to sustained drug delivery, can be implemented with the help of microneedle arrays (MNAs). Aim of Review: Hence, in this paper, we overviewed different kinds of MNAs such as solid/coated, hollow, porous, hydrogel/swellable, and merged-tip geometry followed by introducing different types of material (silicon, glass, ceramics, dissolving and biodegradable polymers, and hydrogel) used for fabrication of MNAs. Afterwards, some conventional and brand-new simple and customizable MN mold fabrication techniques were surveyed. Polymeric MNAs have received a great deal of attention due to their potential biocompatibility and biodegradability in comparison to other materials. Therefore, we also covered different kinds of polymers such as hydrogel/swellable, dissolving and biodegradable analogues used for the development of MNAs as potential candidates in drug delivery systems (DDSs). Finally, we discussed different challenges and future perspectives in the aspect of MNAs-based drug delivery platforms. Key Scientific Concepts of Review: This review may provide guidelines for the rational design of polymeric MNAs-based DDSs for promising programmable drug release and enhanced therapeutic effect.
Languageen
PublisherElsevier B.V.
SubjectBiodegradable polymers
Dissolving polymers
Drug delivery
Fabrication method
Hydrogel polymers
Microneedle array
TitlePolymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems
TypeArticle
Volume Number26
dc.accessType Abstract Only


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