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AuthorAugustine R.
AuthorRehman S.R.U.
AuthorAhmed R.
AuthorZahid A.A.
AuthorSharifi M.
AuthorFalahati M.
AuthorHasan, Anwarul
Available date2022-05-21T10:18:30Z
Publication Date2020
Publication NameInternational Journal of Biological Macromolecules
ResourceScopus
Identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2020.03.207
URIhttp://hdl.handle.net/10576/31301
AbstractElectrospinning is one of the most promising techniques for generating porous, nonwoven, and submicron fiber-based membranes for various applications such as catalysis, sensing, tissue engineering and wound healing. Wide range of biopolymers including chitosan can be used to generate submicron fibrous membranes. Owing to the extra cellular matrix (ECM) mimicking property, exudate uptake capacity, biocompatibility, antibacterial activity and biodegradability, electrospun membranes based on chitosan loaded with biologically active agents can play important role in wound healing applications. In order to improve the mechanical stability, degradation, antimicrobial property, vascularization potential and wound healing capacity, various active components such as other polymers, therapeutic agents, nanoparticles and biomolecules were introduced. Approaches such as coaxial electrospinning with other polymers have also been tried to improve the properties of chitosan membranes. To improve the mechanical stability under in vivo conditions, various crosslinking strategies ranging from physical, chemical and biological approaches were also tried by researchers. Electrospun chitosan meshes have also been designed in a highly specialized manner with specific functionalities to deal with the challenging wound environment of diabetic and burn wounds. This review provides a detailed overview of electrospun chitosan-based membranes containing various bioactive and therapeutic agents in the perspective of wound healing and skin regeneration.
Languageen
PublisherElsevier B.V.
SubjectChitosan
Electrospinning
Skin substitutes
Tissue regeneration
Wound healing
TitleElectrospun chitosan membranes containing bioactive and therapeutic agents for enhanced wound healing
TypeArticle
Volume Number156
dc.accessType Abstract Only


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