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AuthorAl Rifai, N.
AuthorHasan, Anwarul
AuthorKobeissy, F.
AuthorGazalah, H.
AuthorCharara, J.
Available date2022-05-21T10:18:34Z
Publication Date2015
Publication Name2015 International Conference on Advances in Biomedical Engineering, ICABME 2015
ResourceScopus
Identifierhttp://dx.doi.org/10.1109/ICABME.2015.7323300
URIhttp://hdl.handle.net/10576/31335
AbstractRestoration of brain functions following trauma or degenerative neural diseases is considered among the greatest challenges in neurology due to the fact that the central nervous system (CNS) does not regenerate on its own. Tissue engineering offers a potential solution in developing artificial neural/brain tissues. Numerous hydrogel based biomaterials have been investigated in the field of neural tissue engineering. However, the lack of the optimum combination of mechanical and biological properties in commonly available hydrogels represents a major bottle neck in growing artificial neural tissues. In this study, 3 dimensional cell culture of PC12 neuronal cells have been investigated in methacrylated Gelatin (GelMA) hydrogel for brain tissue engineering. The cell viability and propagation of PC12 neural cell lines on GelMA-based hydrogel was tested revealing its positive effects on these cells. In addition, cytotoxicity was assessed in vivo showing that implantation of GelMA did not show any acute neurotoxic effects in mice exposed to experimental brain injury.
Languageen
PublisherInstitute of Electrical and Electronics Engineers Inc.
SubjectGelMA
hydrogels
PC12 cell
tissue engineering
TitleCulture of PC12 neuronal cells in GelMA hydrogel for brain tissue engineering
TypeConference Paper
dc.accessType Abstract Only


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