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المؤلفAbdo, Ghada G.
المؤلفKheraldine, Hadeel
المؤلفGupta, Ishita
المؤلفRizeq, Balsam
المؤلفElzatahry, Ahmed
المؤلفAl Moustafa, Ala-Eddin
المؤلفKhalil, Ashraf
تاريخ الإتاحة2022-05-22T09:12:24Z
تاريخ النشر2020
اسم المنشورJournal of biomedical nanotechnology
المصدرScopus
المعرّفhttp://dx.doi.org/10.1166/jbn.2020.2937
معرّف المصادر الموحدhttp://hdl.handle.net/10576/31363
الملخصImplementation of carbon nanofibers (CNFs) in biomedical applications have successful outcomes, however, they are still considered as a potential hazard. We herein used avian embryos at 3 days and its chorioallantoic membrane (CAM) at 6 days of incubation to evaluate the impact of synthesized CNFs on the early stage of embryogenesis and angiogenesis. Our data point out that 50 ?g/embryo concentration of CNFs provoke adverse effects as 75% of CNFs-exposed embryos die within 1-5 days after exposure compared with their matched controls. Furthermore, CNFs significantly inhibit angiogenesis of the CAM after 48-hours post-treatment. Additionally, RT-PCR analysis on seven key controller genes responsible for proliferation, survival, angiogenesis, and apoptosis showed that these genes are deregulated in brain, heart, and liver tissues of CNFs-exposed embryos compared to their matched control. Our investigation suggests that CNFs could have a toxic effect on the early stages of embryogenesis as well as angiogenesis. Nevertheless, further investigations are required to evaluate the effects of CNFs and elucidate their mechanism on the early stage of the normal development and human health.
اللغةen
الناشرNLM (Medline)
الموضوعcarbon
nanofiber
animal
apoptosis
chorioallantois
human
neovascularization (pathology)
Animals
Apoptosis
Carbon
Chorioallantoic Membrane
Humans
Nanofibers
Neovascularization, Pathologic
العنوانSignificant Toxic Effect of Carbon Nanofibers at the Early Stage of Embryogenesis
النوعArticle
الصفحات975-984
رقم العدد6
رقم المجلد16
dc.accessType Abstract Only


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