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AuthorAbdo, Ghada G.
AuthorKheraldine, Hadeel
AuthorGupta, Ishita
AuthorRizeq, Balsam
AuthorElzatahry, Ahmed
AuthorAl Moustafa, Ala-Eddin
AuthorKhalil, Ashraf
Available date2022-05-22T09:12:24Z
Publication Date2020
Publication NameJournal of biomedical nanotechnology
ResourceScopus
Identifierhttp://dx.doi.org/10.1166/jbn.2020.2937
URIhttp://hdl.handle.net/10576/31363
AbstractImplementation of carbon nanofibers (CNFs) in biomedical applications have successful outcomes, however, they are still considered as a potential hazard. We herein used avian embryos at 3 days and its chorioallantoic membrane (CAM) at 6 days of incubation to evaluate the impact of synthesized CNFs on the early stage of embryogenesis and angiogenesis. Our data point out that 50 ?g/embryo concentration of CNFs provoke adverse effects as 75% of CNFs-exposed embryos die within 1-5 days after exposure compared with their matched controls. Furthermore, CNFs significantly inhibit angiogenesis of the CAM after 48-hours post-treatment. Additionally, RT-PCR analysis on seven key controller genes responsible for proliferation, survival, angiogenesis, and apoptosis showed that these genes are deregulated in brain, heart, and liver tissues of CNFs-exposed embryos compared to their matched control. Our investigation suggests that CNFs could have a toxic effect on the early stages of embryogenesis as well as angiogenesis. Nevertheless, further investigations are required to evaluate the effects of CNFs and elucidate their mechanism on the early stage of the normal development and human health.
Languageen
PublisherNLM (Medline)
Subjectcarbon
nanofiber
animal
apoptosis
chorioallantois
human
neovascularization (pathology)
Animals
Apoptosis
Carbon
Chorioallantoic Membrane
Humans
Nanofibers
Neovascularization, Pathologic
TitleSignificant Toxic Effect of Carbon Nanofibers at the Early Stage of Embryogenesis
TypeArticle
Pagination975-984
Issue Number6
Volume Number16
dc.accessType Abstract Only


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