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AuthorFarooq, M.
AuthorTaha, N. A.
AuthorButorac, R. R.
AuthorEvans, D. A.
AuthorElzatahry, A. A.
AuthorWadaan, M. A. M.
AuthorCowley, A. H.
Available date2022-05-22T09:12:27Z
Publication Date2015
Publication NameAsian Pacific Journal of Cancer Prevention
ResourceScopus
Identifierhttp://dx.doi.org/10.7314/APJCP.2015.16.16.7003
URIhttp://hdl.handle.net/10576/31383
AbstractBackground: Nanoparticles of gold and silver are offering revolutionary changes in the field of cancer therapy. N-heterocyclic carbene (NHC) metal complexes possess diverse biological activities and are being investigated as potential chemotherapeutic agents. The purpose of this study was to examine the cytotoxicity and possible mechanisms of action of two types of newly synthesized nanofiber composites containing BIAN N-heterocyclic gold carbene complexes in two types of human cancer cells, namely breast cancer (MCF7) and liver cancer (HepG2) cells and also in normal human embryonic kidney cells (HEK 293). Materials and Methods: Cytotoxicity was assessed by MTT cell viability assay and oxidative stress by checking the total glutathione level. Results: Both compounds affected the cell survival of the tested cell lines at very low concentrations (IC50 values in the micro molar range) as compared to a well-known anti-cancer drug, 5 fluorouracil. A 60-80% depletion in total glutathione level was detected in treated cells. Conclusions: Reduction in total glutathione level is one of the biochemical pathways for the induction of oxidative stress which in turn could be a possible mechanism of action by which these compounds induce cytotoxicity in cancer cell lines. The in vitro toxicity towards cancer cells found here means that these molecules could be potential anticancer candidates.
Languageen
PublisherAsian Pacific Organization for Cancer Prevention
Subjectacenaphthene derivative
antineoplastic agent
carbene
coordination compound
fluorouracil
glutathione
gold
heterocyclic compound
methane
nanofiber
analogs and derivatives
cell survival
drug effects
HEK293 cell line
HepG2 cell line
human
IC50
MCF 7 cell line
metabolism
oxidative stress
Acenaphthenes
Antineoplastic Agents
Cell Survival
Coordination Complexes
Fluorouracil
Glutathione
Gold
HEK293 Cells
Hep G2 Cells
Heterocyclic Compounds
Humans
Inhibitory Concentration 50
MCF-7 Cells
Methane
Nanofibers
Oxidative Stress
TitleBIAN N-heterocyclic gold carbene complexes induced cytotoxicity in human cancer cells via upregulating oxidative stress
TypeArticle
Pagination7003-7006
Issue Number16
Volume Number16


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