Browsing Medicine Research by Title
Now showing items 639-658 of 1265
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In patients with Chronic Heart Failure Which Polypharmacy Pheno-groups are associated with adverse health outcomes? (Polypharmacy Pheno-groups and Heart failure outcomes)
( Elsevier , 2023 , Article)BackgroundPatients with heart failure are living longer with the inevitable morbidity of rising medication counts. It remains uncertain what fraction of this ensuing polypharmacy exactly predicts adverse clinical outcomes. ... -
In Response: Heterogeneous and dynamic prevalence of asymptomatic influenza virus infections
( Centers for Disease Control and Prevention (CDC) , 2018 , Article)In Response: We thank Leung and Cowling (1) for taking time to comment on our article (2). One problem with the random effects model is the rapid decline in performance of the model as the heterogeneity within studies ... -
In sickness and in health: The politics of public health and their implications during the COVID-19 pandemic
( Wiley , 2021 , Article)Politics is a major player in health, sickness, and death affairs. This article reviews the role of politics in public health and its impact on health outcomes, mortality ratios, and death scenarios amongst the most ... -
In silico virtual screening of lead compounds for major antigenic sites in respiratory syncytial virus fusion protein.
( Springer , 2021 , Article)Human respiratory syncytial virus (RSV) is a leading ubiquitous respiratory pathogen in newborn infants, young children, and the elderly, with no vaccine available to date. The viral fusion glycoprotein (RSV F) plays an ... -
In vitro effects of hydrogen peroxide on rat uterine contraction before and during pregnancy
( Medicinska Naklada Zagreb , 2018 , Article)Aim To assess the in vitro effect of hydrogen peroxide (H 2 O 2 ) on uterine contractions in pregnant and non-pregnant rats. Methods The study was performed at the Department of Physiology, College of Medicine, King Saud ... -
In vitro evaluation of Neosetophomone B inducing apoptosis in cutaneous T cell lymphoma by targeting the FOXM1 signaling pathway
( Elsevier , 2023 , Article)Background: Cutaneous T cell lymphoma (CTCL) is a T cell-derived non-Hodgkin lymphoma primarily affecting the skin, with treatment posing a significant challenge and low survival rates. Objective: In this study, we ... -
In-frame fusion of SUMO1 enhances βarrestin2's association with activated GPCRs as well as with nuclear pore complexes
( Elsevier , 2020 , Article)Small ubiquitin like modifier (SUMO) conjugation or SUMOylation of βarrestin2 promotes its association with the clathrin adaptor protein AP2 and facilitates rapid β2 adrenergic receptor (β2AR) internalization. However, ... -
Incidence and association of high-risk HPVs and EBV in patients with advanced stages of colorectal cancer from Qatar
( Taylor and Francis Ltd. , 2023 , Article)High-risk Human Papillomaviruses (HPVs) and Epstein-Barr virus (EBV) are present and involved in several types of human carcinomas, including cervical and, head and neck cancers. Nevertheless, their presence and association ... -
Incidence of HPVs, EBV and MMTV-like Virus in Breast Cancer in Qatar.
( Karger Publishers , 2022 , Article)Human papillomaviruses (HPVs), Epstein-Barr virus (EBV), and mouse mammary tumor virus-like virus (MMTV-like virus) can be present and contribute to breast cancer development and progression. However, the role of these ... -
Increased cellular protein modification by methylglyoxal activates endoplasmic reticulum-based sensors of the unfolded protein response
( Elsevier B.V. , 2024 , Article)The unfolded protein response (UPR) detects increased misfolded proteins and activates protein refolding, protein degradation and inflammatory responses. UPR sensors in the endoplasmic reticulum, IRE1α and PERK, bind and ... -
Increased de novo DNA methylation enzymes in sperm of individuals with varicocele
( pmc , 2021 , Article)Objective: Chronic genital heat-stress associated with varicocele leads to DNA hypo-methylation of spermatozoa. The objective of this study was comparing level of DNA methyl-transferases (DNMTs) in sperm of men suffering ... -
Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis
( American Society for Clinical Investigation , 2022 , Article)People with kidney disease are disproportionately affected by atherosclerosis for unclear reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived mediator of kidney disease, levels of which ... -
An infant with ankyloblepharon filiforme adnatum associated with a cleft lip and palate: A case report
( Elsevier , 2022 , Other)Ankyloblepharon filiform adnatum (AFA) is a rare but potentially ambylogenic congenital anomaly characterized by a partial or complete fusion of the eyelid margins.1 Although AFA has been reported as an isolated finding, ... -
Infantile hypertrophic pyloric stenosis in Bosnia and Herzegovina: A retrospective cohort study from the largest tertiary care facility
( Elsevier , 2021 , Article)Background Infantile hypertrophic pyloric stenosis (IHPS) is the most common condition requiring surgery in infancy, but the etiology of IHPS is still unclear. The study aimed to analyze the epidemiological and clinical ... -
Infection with Helicobacter pylori may predispose to atherosclerosis: role of inflammation and thickening of intima-media of carotid arteries
( Frontiers Media , 2023 , Article Review)Atherosclerosis is a major instigator of cardiovascular disease (CVD) and a main cause of global morbidity and mortality. The high prevalence of CVD calls for urgent attention to possible preventive measures in order to ... -
Inflammasomes as biomarkers and therapeutic targets in traumatic brain injury and related-neurodegenerative diseases: A comprehensive overview
( Elsevier , 2023 , Article)Given the ambiguity surrounding traumatic brain injury (TBI) pathophysiology and the lack of any Food and Drug Administration (FDA)-approved neurotherapeutic drugs, there is an increasing need to better understand the ... -
Inflammatory protein signatures in individuals with obesity and metabolic syndrome
( Springer Nature , 2023 , Article)There is variability in the metabolic health status among individuals presenting with obesity; some may be metabolically healthy, while others may have developed the metabolic syndrome, a cluster including insulin resistance, ... -
The influence of maternal blood glucose during pregnancy on weight outcomes at birth and preschool age in offspring exposed to hyperglycemia first detected during pregnancy, in a South African cohort.
( Public Library of Science , 2021 , Article)Little is known about the influence of hyperglycemia first detected in pregnancy (HFDP) on weight outcomes in exposed offspring in Africa. We investigated the influence of maternal blood glucose concentrations during ... -
Information on harm outcomes was insufficiently reported in systematic reviews and meta-analyses of individual participant data
( John Wiley and Sons Inc , 2021 , Other)Meta-analysis is an important tool for summarizing findings from scientific research. But for harm outcomes,issues may arise due to the distribution problems, zero-events problems, as well as low statistical power. Individual ... -
Information, Thermodynamics and Life: A Narrative Review
( MDPI , 2021 , Article Review)Information is probably one of the most difficult physical quantities to comprehend. This applies not only to the very definition of information, but also to the physical entity of information, meaning how can it be ...