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New insight into the role of PTCH1 protein in serous ovarian carcinomas.
(
Spandidos Publications
, 2022 , Article)
The Hedgehog (Hh) signaling pathway is essential for normal embryonic development, while its hyperactivation in the adult organism is associated with the development of various cancers. The role of the Hh signaling pathway ...
Systemic antibiotic sales and WHO recommendations, India.
(
World Health Organization
, 2022 , Article)
To analyse sales of fixed-dose combination and single antibiotics in India in relation to World Health Organization (WHO) recommendations and national regulatory efforts to control antibiotic sales. We extracted data on ...
Multimorbidity, healthcare use and catastrophic health expenditure by households in India: a cross-section analysis of self-reported morbidity from national sample survey data 2017–18
(
BMC
, 2022 , Article)
Background: The purpose of this research is to generate new evidence on the economic consequences of multimorbidity on households in terms of out-of-pocket (OOP) expenditures and their implications for catastrophic OOP ...
Clinical outcomes of Pfizer-BioNTech COVID-19 vaccine in children and adolescents: A systematic review
(
John Wiley and Sons Inc
, 2022 , Article Review)
Background & Aims: The BioNTech-Pfizer vaccine is the only vaccine offered to children among all available vaccines. However, limited evidence is available about the clinical outcomes of COVID-19 vaccines, especially among ...
Quantification of the growth suppression of HER2+ breast cancer colonies under the effect of trastuzumab and PD-1/PD-L1 inhibitor.
(
Frontiers Media
, 2022 , Article)
Immune checkpoint blockade (ICB)-based therapy is revolutionizing cancer treatment by fostering successful immune surveillance and effector cell responses against various types of cancers. However, patients with HER2+ ...
F-box proteins in cancer stemness: An emerging prognostic and therapeutic target
(
Elsevier
, 2021 , Article)
Cancer is a complex heterogenic disease with significant therapeutic challenges. The presence of cancer stem cells (CSCs) in cancer tissue orchestrates tumor growth, progression, and metastasis, the tumor heterogeneity, ...
Comparison of demographic and clinical characteristics in distinguishing testicular torsion from torsion of the appendix testis: A single-center retrospective study
(
Elsevier
, 2022 , Article)
Testicular torsion (TT) is an emergency requiring a prompt diagnosis and surgery to avoid irreversible changes and a complete loss of testis. The present study aimed to identify potential factors that may predict a testicular ...
Frequency of Parathyroid Hormone Assessment in the Evaluation of Hypercalcemia. A Comparison Between Patients With and Without a History of Malignancy in a 20-year Dataset of 20,954 Patients
(
SAGE Publications Ltd
, 2021 , Article)
Background: The purpose of this study was to evaluate whether a prior diagnosis of malignancy affected the assessment of parathyroid hormone (PTH) in hypercalcemic patients and whether the rate of this assessment changed ...
The Odds Ratio is "portable" across baseline risk but not the Relative Risk: Time to do away with the log link in binomial regression
(
Elsevier Inc.
, 2022 , Article)
Objectives: In a recent paper we suggest that the relative risk (RR) be replaced with the odds ratio (OR) as the effect measure of choice in clinical epidemiology. In response, Chu, and colleagues raise several points that ...
Towards a better understanding of self-management interventions in type 2 diabetes: A concept analysis
(
Elsevier Ltd
, 2022 , Article)
Objectives: Diabetes self-management educational (DSME) interventions can vary considerably, and it is unclear what is the operational conceptualization of the ideal delivery to individuals with type 2 diabetes (T2D). ...