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Novel therapeutic targets in salivary duct carcinoma uncovered by comprehensive molecular profiling.
(
Wiley Open Access
, 2019 , Article)
Salivary duct carcinoma (SDC) is a rare, aggressive salivary gland malignancy, which often presents at an advanced stage. A proportion of SDC are characterized by HER2 amplification and/or overexpression of androgen receptor ...
Potential Novel Therapy Targets in Neuroendocrine Carcinomas of the Breast.
(
Elsevier
, 2018 , Article)
Neuroendocrine carcinoma (NEC) of the breast is a rare, special type of breast cancer, reportedly constituting 2% to 5% of all breast cancers. Although breast NEC does not have a specific targeted therapy, several new ...
Molecular Profiling of Clear Cell Carcinoma of the Breast Reveals Novel Targetable Biomarkers
(
Springer Nature
, 2020 , Conference Paper)
Background: Although clear cell morphology may be seen in various subtypes of breast cancer, a pure variant of clear cell carcinoma (usually glycogen-rich) is a very rare primary breast malignancy. It is characterized by ...
Molecular profiling of the metaplastic spindle cell carcinoma of the breast reveals potentially targetable biomarkers
(
Elsevier
, 2020 , Article)
IntroductionSpindle cell carcinoma is a rare subtype of metaplastic breast cancer (MBC), with triple-negative (TNBC: ER-/PR-/Her2-) phenotype. It is associated with a marked resistance to conventional chemotherapy and has ...
Novel targetable biomarkers in clear cell carcinoma of the breast uncovered by molecular profiling: A study of nine cases.
(
Wiley
, 2020 , Article)
We profiled nine pure clear cell carcinomas of the breast using massively parallel DNA and RNA sequencing (NGS), in situ hybridization (ISH), and immunohistochemistry (IHC). All cases were primary mammary clear cell ...
Comprehensive molecular profiling of advanced/metastatic olfactory neuroblastomas.
(
Public Library of Science
, 2018 , Article)
Olfactory neuroblastoma (ONB) is a rare, locally aggressive, malignant neoplasm originating in the olfactory epithelium in the nasal vault. The recurrence rate of ONB remains high and there are no specific treatment ...
Molecular Profiling Reveals Limited Targetable Biomarkers in Neuroendocrine Carcinoma of the Cervix.
(
Lippincott, Williams & Wilkins
, 2020 , Article)
Neuroendocrine carcinoma of the cervix (NEC) is a rare and highly aggressive cervical malignancy. Given that no targeted therapy has been approved specifically to NEC, we investigated the presence of novel, potentially ...
Molecular characterization of cancers with NTRK gene fusions
(
Springer Nature
, 2019 , Article)
Targeted inhibitors of neurotropic tyrosine kinases are highly effective in selected patients with gene fusions involving NTRK1, NTRK2, or NTRK3. These fusions are consistently detected in rare cancer types (e.g., secretory ...
TERT gene fusions characterize a subset of metastatic Leydig cell tumors
(
Elsevier
, 2021 , Article)
Objective: Metastatic Leydig cell tumors (LCT) are rare, difficult to treat malignancies without known underlying molecular-genetic events. An index case of metastatic LCT showed an LDLR-TERT gene fusion upon routine genetic ...
Theranostic molecular profiling of pleomorphic ductal carcinoma of the breast.
(
Wiley
, 2019 , Other)
Pleomorphic ductal carcinoma (PDC) is a very rare subtype of invasive ductal carcinoma of no‐special type (NST), characterized by the presence of highly atypical/bizarre (>6‐fold variation in nuclear size) and multinucleated ...