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Sanguinarine Triggers Apoptosis in Cutaneous Squamous Cell Carcinoma Cells through Reactive Oxygen Species-Dependent c-Jun N-Terminal Kinase Signaling Pathway
(
IMR Press Limited
, 2024 , Article)
Background: The benzophenanthridine Sanguinarine (Sng) is one of the most abundant root alkaloids with a long history of investigation and pharmaceutical applications. The cytotoxicity of Sng against various tumor cells ...
Navigating the evolving landscape of atopic dermatitis: Challenges and future opportunities: The 4th Davos declaration
(
John Wiley and Sons
, 2024 , Article)
The 4th Davos Declaration was developed during the Global Allergy Forum in Davos which aimed to elevate the care of patients with atopic dermatitis (AD) by uniting experts and stakeholders. The forum addressed the high ...
Metabolomics analyses reveal the crucial role of ERK in regulating metabolic pathways associated with the proliferation of human cutaneous T-cell lymphoma cells treated with Glabridin
(
John Wiley and Sons
, 2024 , Article)
Cutaneous T-cell lymphomas (CTC) are a heterogeneous group of T-cell lymphoproliferative malignancies of the skin with limited treatment options, increased resistance and remission. Metabolic reprogramming is vital in ...
Retrospective evaluation of a TEN/SJS series managed with a new treatment protocol
(
John Wiley and Sons
, 2024 , Other)
Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening diseases without standardized treatment. The mortality rate ranges from 20% to 50%, and can reach up to 90%, based on the ...
Severe atopic dermatitis in an Asian-Arabic population treated with dupilumab: A retrospective observational study
(
John Wiley and Sons
, 2024 , Other)
Atopic dermatitis (AD) is a common, inflammatory skin disease characterized by a TH2-deviated immune response in the acute phase and a TH2/TH1/TH17/TH22-skewed immune response in the chronic phase1 associated with pruritus. ...
Azithromycin targets the CD27 pathway to modulate CD27hi T-lymphocyte expansion and type-1 effector phenotype
(
Frontiers Media SA
, 2024 , Article)
Macrolide antibiotic azithromycin is widely used in clinical practice to treat respiratory tract infections and inflammatory diseases. However, its mechanism of action is not fully understood. Given the involvement of the ...
Editorial: Itch treatments
(
Frontiers Media SA
, 2024 , Article)
no Abstract
Development of a 43 color panel for the characterization of conventional and unconventional T-cell subsets, B cells, NK cells, monocytes, dendritic cells, and innate lymphoid cells using spectral flow cytometry
(
John Wiley and Sons Inc
, 2024 , Article)
Although many flow cytometers can analyze 30–50 parameters, it is still challenging to develop a 40+ color panel for the phenotyping of immune cells using fluorochrome conjugated antibodies due to limitations in the ...
Recalcitrant pityriasis rubra pilaris in a Middle Eastern patient and arguments for early anti-IL-23 targeting
(
John Wiley and Sons Inc
, 2024 , Article)
Pityriasis rubra pilaris (PRP) is a rare, chronic cutaneous inflammatory disorder of keratinization affecting adults, children and patients with HIV. The pathogenesis of PRP is not fully understood with clinical presentations, ...
Impact of Previous Alopecia Areata Treatment on Efficacy Responses up to Week 48 Following Ritlecitinib Treatment: A Post Hoc Analysis
(
Springer
, 2024 , Article)
Introduction
Patients with alopecia areata (AA) may have received several therapies for management of AA during their lives. In the ALLEGRO phase 2b/3 (NCT03732807) study, the oral JAK3/TEC family kinase inhibitor ...