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Chronic administration of nano-sized PAMAM dendrimers in vivo inhibits EGFR-ERK1/2-ROCK signaling pathway and attenuates diabetes-induced vascular remodeling and dysfunction.
(
Elsevier
, 2019 , Article)
We investigated whether chronic administration of nano-sized polyamidoamine (PAMAM) dendrimers can have beneficial effects on diabetes-induced vascular dysfunction by inhibiting the epidermal growth factor receptor ...
Identifying essential competencies for medical students
(
Emerald Group Publishing Ltd.
, 2019 , Article)
Purpose
The purpose of this paper is to identify essential profession-related competencies, clinical knowledge and skills that medical students should develop in the early stages of their education for future professional ...
Neuropathic itch
(
NLM (Medline)
, 2019 , Article)
Neuropathic itch is clinically important but has received much less attention as compared to neuropathic pain. In the past decade, itch-specific pathways have been characterized on a cellular and molecular level, but their ...
Meta-analysis of intracavitary electrocardiogram guidance for peripherally inserted central catheter placement
(
SAGE Publications Ltd
, 2019 , Article Review)
Background:
Recently, intracavitary electrocardiogram technology has been applied to peripherally inserted central catheter placement and demonstrates many potential advantages. However, the tip positioning accuracy of ...
The purification and identification of human blood serum proteins with affinity to the antitumor active RL2 lactaptin using magnetic microparticles
(
John Wiley and Sons Ltd
, 2019 , Article)
The cytopoxic effect of RL2 lactaptin (the recombinant analog of proteolytic fragment of human kappa‐casein) toward tumor cells in vitro and in vivo presents it as a novel promising antitumor drug. The binding of any drug ...
Reinforcement learning-based control of tumor growth under anti-angiogenic therapy.
(
Elsevier
, 2019 , Article)
In recent decades, cancer has become one of the most fatal and destructive diseases which is threatening humans life. Accordingly, different types of cancer treatment are studied with the main aim to have the best treatment ...
Dishevelled family proteins in serous ovarian carcinomas: A clinicopathologic and molecular study
(
Wiley
, 2019 , Article)
Dishevelled family proteins (DVL1, DVL2 and DVL3) are cytoplasmic mediators involved in canonical and non-canonical Wnt signaling that are important for embryonic development. Since Wnt signaling promotes cell proliferation ...
Titanium Nanorods Loaded PCL Meshes with Enhanced Blood Vessel Formation and Cell Migration for Wound Dressing Applications.
(
Wiley
, 2019 , Article)
Proper management of nonhealing wounds is an imperative clinical challenge. For the effective healing of chronic wounds, suitable wound coverage materials with the capability to accelerate cell migration, cell proliferation, ...
Efficacy of Anthelminthic Drugs and Drug Combinations Against Soil-transmitted Helminths: A Systematic Review and Network Meta-analysis.
(
Oxford University Press
, 2019 , Article)
Periodic mass distribution of benzimidazole anthelminthic drugs is the key strategy to control soil-transmitted helminths (STHs) globally. However, benzimidazoles have low efficacy against Trichuris trichiura, and there ...
The risk of developing major depression among individuals with subthreshold depression: a systematic review and meta-analysis of longitudinal cohort studies.
(
Cambridge University Press
, 2019 , Article)
Studies have consistently shown that subthreshold depression is associated with an increased risk of developing major depression. However, no study has yet calculated a pooled estimate that quantifies the magnitude of this ...