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The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.
(
Springer Nature
, 2020 , Article)
Kaufman oculocerebrofacial syndrome (KOS) is a severe autosomal recessive disorder characterized by intellectual disability, developmental delays, microcephaly, and characteristic dysmorphisms. Biallelic mutations of UBE3B, ...
EGFR Inhibitor Gefitinib Induces Cardiotoxicity through the Modulation of Cardiac PTEN/Akt/FoxO3a Pathway and Reactive Metabolites Formation: and Rat Studies.
(
American Chemical Society
, 2020 , Article)
Gefitinib (GEF) is a selective inhibitor of the epidermal growth factor receptor (EGFR) used to treat non-small cell lung cancer. Yet, few cases of cardiotoxicity have been reported. However, the role of the PTEN/Akt/FoxO3a ...
Acute glans ischemia after circumcision successfully treated with low-molecular-weight heparin and topical dihydrotestosterone: A case report
(
Wolters Kluwer Health
, 2020 , Article)
Circumcision like any other surgical procedure is not devoid of complications. Serious complications are rare and include iatrogenic hypospadias, glans ischemia/necrosis, and glans amputation, all of which require an ...
Genome-wide polygenic score, clinical risk factors, and long-term trajectories of coronary artery disease
(
American Heart Association
, 2020 , Article)
OBJECTIVE: To determine the relationship of a genome-wide polygenic score for coronary artery disease (GPSCAD) with lifetime trajectories of CAD risk, directly compare its predictive capacity to traditional risk factors, ...
Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale
(
Nature Research
, 2020 , Article)
Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes. Commonly used RV association tests have limited scope to leverage variant functions. We propose ...
Transethnic Transferability of a Genome-wide Polygenic Score for Coronary Artery Disease.
(
American Heart Association
, 2020 , Article)
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Green synthesis and chemical characterization of gold nanoparticle synthesized using Camellia sinensis leaf aqueous extract for the treatment of acute myeloid leukemia in comparison to daunorubicin in a leukemic mouse model
(
Wiley
, 2020 , Article)
© 2020 John Wiley & Sons, Ltd. According to chemotherapeutic properties of medicinal plants, pharmacologists have always tried to synthesize and formulate the new chemotherapeutic supplements or drugs of metallic ...
Molecular Profiling of Clear Cell Carcinoma of the Breast Reveals Novel Targetable Biomarkers
(
Springer Nature
, 2020 , Conference Paper)
Background: Although clear cell morphology may be seen in various subtypes of breast cancer, a pure variant of clear cell carcinoma (usually glycogen-rich) is a very rare primary breast malignancy. It is characterized by ...
High-Risk Human Papillomaviruses (HPV) and Epstein - Barr virus (EBV) are Commonly Present in Rectal Cancer
(
Springer Nature
, 2020 , Conference Paper)
Background: Human papillomaviruses (HPVs) and Epstein–Barr virus (EBV) are well-established oncoviruses that can be co-present and cooperate in the initiation and/or progression of various human cancers. We recently reported ...
Apple-peel jejunal atresia associated with multiple ileal atresias in a preterm newborn: A rare congenital anomaly.
(
Wiley
, 2020 , Article)
The apple‐peel type of jejunal atresia is the rarest form (1:50 000) of all small intestinal atresias. This anomaly is characterised by a proximal jejunal atresia associated with a typical coil‐shaped distal small bowel. ...