Medicine Research: Recent submissions

Now showing items 1081-1100 of 1820

    • Neurotrauma investigation through spatial omics guided by mass spectrometry imaging: Target identification and clinical applications 

      Mallah, Khalil; Zibara, Kazem; Kerbaj, Coline; Eid, Ali; Khoshman, Nour; ... more authors ( Wiley , 2023 , Article Review)
      Traumatic brain injury (TBI) represents one of the major public health concerns worldwide due to the increase in TBI incidence as a result of injuries from daily life accidents such as sports and motor vehicle transportation ...

    • Oral Vaccine Delivery: The Coming Age of Particulate Vaccines to Elicit Mucosal Immunity 

      Gala, Rikhav P.; Bajaj, Lotika; Bansal, Amit; Gomes, Keegan Braz; Joshi, Devyani; ... more authors ( Springer , 2020 , Book chapter)
      With the evolution of different challenging diseases, there is an urgent need of vaccine development against them to save millions of lives around the world. Particlulate delivery system plays an important role by acting ...

    • Antigen Unmasking Is Required to Clinically Assess Levels and Localisation Patterns of Phospholipase C Zeta in Human Sperm 

      Kashir, Junaid; Mistry, Bhavesh V.; BuSaleh, Lujain; Nomikos, Michail; Almuqayyil, Sarah; ... more authors ( MDPI , 2023 , Article)
      Mammalian oocyte activation is initiated by intracellular calcium (Ca2+) oscillations, driven by the testis-specific phospholipase C zeta (PLCζ). Sperm PLCζ analysis represents a diagnostic measure of sperm fertilisation ...

    • Clinical presentation and outcomes of peripartum cardiomyopathy in the Middle East: a cohort from seven Arab countries 

      Salam, Amar M.; Ahmed, Mohamed Badie; Sulaiman, Kadhim; Singh, Rajvir; Alhashemi, Mohammed; ... more authors ( Wiley , 2020 , Article)
      Aims: Published data on the clinical presentation of peripartum cardiomyopathy (PPCM) are very limited particularly from the Middle East. The aim of this study was to examine the clinical presentation, management, and ...

    • A possible role for inducible arginase isoform (AI) in the pathogenesis of chronic venous leg ulcer 

      Abd El-Aleem, Seham A.; Abd-Elghany, Manal Ismail; Ali Saber, Entesar; Jude, Edward B.; Djouhri, Laiche ( Wiley , 2020 , Article)
      Chronic venous ulcer (CVU) is a major cause of chronic wounds of lower extremities and presents a significant financial and resource burden to health care systems worldwide. Defects in the vasculature, matrix deposition, ...

    • Epac as a tractable therapeutic target 

      Hasan, Slika; Mansour, Hadi; Nasser, Suzanne A.; Shaito, Abdullah; Kobeissy, Firas; ... more authors ( Elsevier , 2023 , Article)
      In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the first signaling cascade discovered was the cAMP-protein kinase A (PKA) pathway. Since then, cAMP has received increasing ...

    • Efficiency and productivity of health systems in prevention and control of non-communicable diseases in China, 2008–2015 

      Chai, Peipei; Wan, Quan; Kinfu, Yohannes ( Springer , 2021 , Article)
      This article examines the health system performance impact of China’s new round of healthcare reform adopted in 2009. Specifically, we evaluated productivity and efficiency of health production pre- and post-reform period, ...

    • Dicarbonyl stress, protein glycation and the unfolded protein response 

      Rabbani, Naila; Xue, Mingzhan; Thornalley, Paul J. ( Springer , 2021 , Article Review)
      The reactive dicarbonyl metabolite, methylglyoxal (MG), is increased in obesity and diabetes and is implicated in the development of insulin resistance, type 2 diabetes mellitus and vascular complications of diabetes. ...

    • Novel Post-translational Modifications in Human Serum Albumin 

      Kannan, Surya; Krishnankutty, Roopesh; Souchelnytskyi, Serhiy ( Bentham , 2022 , Article)
      Aim: This study aims to identify novel post-translational modifications in human serum albumin by mass spectrometry. Background: Serum albumin is the most abundant protein in plasma, has many physiological functions, and ...

    • Targeted and systemic insights into the crosstalk between DNA-dependent protein kinase catalytic subunit and receptors of estrogen, progesterone and epidermal growth factor in the context of cancer 

      Ansari, Soubiya Mohammed Rizwan; Hijazi, Farah Saleh; Souchelnytskyi, Serhiy ( Springer , 2021 , Article)
      DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has emerged as a regulator of carcinogenesis. Increased expression of DNA-PKcs correlates with metastatic cancers. Here we review recently reported crosstalk of ...

    • Ultrasound controlled paclitaxel releasing system—A novel method for improving the availability of coronary artery drug coated balloon 

      Song, Caixia; Zhou, Chao; Zhang, Junwei; Feng, Xiangyi; Cui, Xiaoshan; ... more authors ( Wiley , 2020 , Article)
      Objectives: The aim of this study is to improve local-drug delivery efficiency and tissue absorption using the ultrasound (US)-responsible drug coating based on a newly developed US-controlled paclitaxel release balloon. ...

    • Association of Habitual Alcohol Intake with Risk of Cardiovascular Disease 

      Biddinger, Kiran J.; Emdin, Connor A.; Haas, Mary E.; Wang, Minxian; Hindy, George; ... more authors ( American Medical Association , 2022 , Article)
      Importance: Observational studies have consistently proposed cardiovascular benefits associated with light alcohol consumption, while recent genetic analyses (ie, mendelian randomization studies) have suggested a possible ...

    • Sociocultural insights on dementia care-giving in Arab and Muslim communities: The perspectives of family care-givers 

      Hammad, Suzanne H.; Daher-Nashif, Suhad; Kane, Tanya; Al-Wattary, Noor ( Cambridge University Press , 2022 , Article)
      Little is known about the experiences of informal family care-giving for persons with ADRD in the context of Arab and Muslim communities. This paper offers fresh insight into the less-studied private sphere of the home, ...

    • NADPH-derived ROS generation drives fibrosis and endothelial-to-mesenchymal transition in systemic sclerosis: Potential cross talk with circulating miRNAs 

      Posadino, Anna Maria; Erre, Gian Luca; Cossu, Annalisa; Emanueli, Costanza; Eid, Ali H.; ... more authors ( Walter de Gruyter , 2022 , Article)
      Systemic sclerosis (SSc) is an immune disorder characterized by diffuse fibrosis and vascular abnormalities of the affected organs. Although the etiopathology of this disease is largely unknown, endothelial damage and ...

    • Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes 

      George, Hindy; Dornbos, Peter; Chaffin, Mark D.; Liu, Dajiang J.; Wang, Minxian; ... more authors ( Elsevier , 2022 , Article)
      Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele ...

    • Review of Post-translational Modification of Human Serum Albumin 

      Kannan, Surya; Souchelnytskyi, Serhiy ( Bentham , 2022 , Article)
      Post-translational modifications (PTMs) may affect the functions of human serum albumin. Here we review reports of novel PTMs of human serum albumin. This study reviewed one hundred twenty-three recently reported novel ...

    • Screening for diabetes and impaired glucose metabolism in Qatar: Models’ development and validation 

      Sadek, Khaled; Abdelhafez, Ibrahim; Al-Hashimi, Israa; Al-Shafi, Wadha; Tarmizi, Fatihah; ... more authors ( Elsevier , 2021 , Article)
      AimTo establish two scoring models for identifying individuals at risk of developing Impaired Glucose Metabolism (IGM) or Type two Diabetes Mellitus (T2DM) in Qatari. Materials and methodsA sample of 2000 individuals, from ...

    • Adipose tissue mitochondrial dysfunction and cardiometabolic diseases: On the search for novel molecular targets 

      Ibrahim, AlZaim; Eid, Ali H.; Abd-Elrahman, Khaled S.; El-Yazbi, Ahmed F. ( Elsevier , 2022 , Article)
      Cardiometabolic diseases present an escalating global health and economic burden. Such a surge is driven by epidemic prevalence rates of metabolic disorders, such as obesity and type 2 diabetes, and their associated ...

    • High fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury 

      Stanley, Ibeh; Bakkar, Nour-Mounira Z.; Ahmad, Fatima; Nwaiwu, Judith; Barsa, Chloe; ... more authors ( Elsevier , 2023 , Article)
      AimsTraumatic brain injury (TBI) constitutes a serious public health concern. Although TBI targets the brain, it can exert several systemic effects which can worsen the complications observed in TBI subjects. Currently, ...

    • Diagnostic Value of Non-invasive Liver Function Tests in Liver Fibrosis and Changes in These Parameters Post-metabolic Surgery 

      Jangjoo, Sara; Emami, Nima; Sahranavard, Mehrdad; Shah, Najeeb Z.; Alidadi, Mona; ... more authors ( Springer , 2023 , Article)
      Purpose: This study aimed to ascertain the diagnostic accuracy of non-invasive liver function tests in liver fibrosis and assess their changes after metabolic surgery. Materials and Methods: 1005 individuals with severe ...