Medicine Research
Recent Submissions
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Leveraging Machine and Deep Learning Algorithms for hERG Blocker Prediction
( Institute of Electrical and Electronics Engineers Inc. (IEEE) , 2025 , Article)The human ether-a-go-go-related (hERG) gene is crucial in enabling the regulation of repolarisation process in the heart. Some chemicals act as hERG blockers, resulting in prolonged QT intervals. Predicting the binding ... -
Rethinking the Diagnosis and Management of Antibody-Mediated Rejection in Multidisciplinary Transplant Meetings: A Global Survey and Banff Working Group Recommendations
( John Wiley & Sons , 2025 , Article)Introduction: The diagnosis of antibody-mediated rejection (AMR) requires input from several transplant professionals. Bringing clinical and laboratory experts together may help standardize care. Yet, little is known about ... -
Psychosocial Evaluation of Prospective Living Kidney Donors in Qatar: A Profile of Prospective Donors, Process, and Outcomes
( Wolters Kluwer Health , 2025 , Article)Background. In Qatar, the Committee for Oversight of Living Donation (COLD) was established at Hamad Medical Corporation in 2014 to provide standardized, multidisciplinary psychosocial evaluation (PE) for prospective living ... -
Digital twins for the era of personalized surgery
( Springer Nature , 2025 , Article)Digital twins can aid surgeons in training and in performing interventions with greater awareness and precision. The range and variety of digital twins in surgery are described, and their use across perioperative care is ... -
Kounis syndrome: acute myocardial injury triggered by ant bite-induced anaphylaxis
( Oxford University Press , 2025 , Article)Anaphylaxis triggered by insect bites is well-documented, but its association with acute myocardial injury (AMI) is rare. We report a case of Kounis syndrome, where an ant bite induced anaphylaxis and myocardial injury. A ... -
From Knowledge to Habits: Changes in COVID-19 Health Attitudes, Practices, and Sources of Information (HAPS) at Qatar University Post-Pandemic.
( Wiley , 2025 , Article)The COVID-19 pandemic has profoundly impacted health behaviors globally and this study investigated changes in Health, Attitudes, Practices, and Sources of information (HAPS) among 1186 students, faculty, and staff at Qatar ... -
Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021
( Elsevier , 2025 , Article)BackgroundDecades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and ... -
Association of physical activity level during pregnancy with preterm birth and infant adiposity: longitudinal analysis from the MAASTHI cohort, India
( Springer Nature , 2025 , Article)Background: Physical activity during pregnancy is thought to influence birth outcomes, but its association with it is not fully understood. We aimed to examine the association of sedentary behavior during pregnancy with ... -
The impact of pre-existing immunity on the emergence of within-host immune-escape mutations in Omicron lineages
( Microbiology Society , 2025 , Article)The Omicron variant of SARS-CoV-2 circulating amongst highly immunized populations is anticipated to induce immunological pressures, potentially compromising existing immunity. This study investigates vaccine-induced ... -
Shaping the future of cell and gene therapy workforce development: training of cell therapy processing personnel - perspectives from the International Society for Cell & Gene Therapy Lab Practices Committee
( Elsevier , 2025 , Article)BackgroundThe field of cell and gene therapy (CGT) is expanding at a rapid rate. CGT workforce shortage is a growing concern, and high-quality training programs are essential to keep up with the increasing demand for ... -
Prospective registration was associated with a reduced risk of bias for randomized controlled trials: a meta-research study
( Elsevier , 2025 , Article)ObjectivesTo investigate the association between trial registration and the risk of bias (RoB). Study Design and SettingsRandomized controlled trials (RCTs) from systematic reviews of medication-related harm published ... -
Proteomic analysis reveals potential biomarker candidates in serous ovarian tumors – a preliminary study
( Termedia Publishing House Ltd. , 2025 , Article)Introduction: Ovarian serous cystadenocarcinoma (SCA), a deadly gynecologic cancer, often goes undetected until the late stages. Tissue proteomics unveils disease heterogeneity, enhancing tumor classification and enabling ... -
Size Increment During Surveillance in Papillary Thyroid Cancer: Evidence Synthesis and Dose–Response Meta-Analysis
( John Wiley & Sons , 2025 , Article)Introduction: Differentiated thyroid cancer has become a prevalent malignant tumor, particularly papillary thyroid carcinoma (PTC), constituting over 90% of cases. Most PTC lesions are asymptomatic and remain subclinical ... -
Reply to Editorial Comment on “Hypospadias Reconstruction Training: Development of an Ex-Vivo Model for Objective Evaluation of Surgical Skills”
( Elsevier , 2025 , Article)W e sincerely appreciate the thoughtful feedback provided. The objective nature of the comments aligns closely with the goals of our work. As noted, this study1 was primarily aimed at evaluating technical skills in a ... -
Risk of Serious Infections in Patients Treated With Biologic or Targeted-synthetic Disease Modifying Antirheumatic Drugs in Qatar
( John Wiley & Sons , 2025 , Article)Background: Biologic and targeted-synthetic disease-modifying antirheumatic drugs (b/tsDMARDs), are pivotal in the management of autoimmune-inflammatory disorders, acting by suppressing pathological immune activation. ... -
Effects of perinatal variables on echocardiographic assessments of left ventricular dimensions in infants born large for gestational age: a prospective cohort analysis
( Springer Nature , 2025 , Article)Background: To assess the relationship between perinatal factors, and echocardiographic left ventricular (LV) dimensions after delivery in infants who are large for gestational age (LGA). Methods: This prospective cohort ... -
The disease-linked R336C mutation in cystathionine β-synthase disrupts communication with the PLP cofactor, yet maintains the enzyme's overall structural integrity
( John Wiley & Sons , 2025 , Article)Cystathionine β-synthase (CBS) is a pyridoxal-phosphate (PLP)-dependent enzyme essential for the reverse transsulfuration pathway, where homocysteine and serine combine to form cystathionine, the immediate precursor of ... -
Cross-Organ Investigation of Tumor Histological Features Similarities Using Transfer Learning: A Case Study on Breast and Colorectal Tumors
( Springer Science and Business Media Deutschland GmbH , 2025 , Conference)Breast and colorectal cancers are two of the most commonly occurring cancers in the world. Transfer Learning with models pre-trained on ImageNet has been extensively used in the literature in the detection of these two ... -
A multicenter mixed-methods study on the effects of intermittent fasting in patients with immune thrombocytopenia receiving thrombopoietin receptor agonists
( Frontiers Media SA , 2025 , Article)Introduction: In recent years, significant advances have been made in the treatment of immune thrombocytopenia (ITP) with the development of thrombopoietin receptor agonists (TPO-RAs). TPO-RAs are often used following the ... -
Long-term renal function post-pyeloplasty: a systematic review
( Springer Science and Business Media B.V. , 2025 , Article Review)Introduction: Ureteropelvic junction obstruction (UPJO) is a significant cause of functional impairment in neonatal kidneys. The gold-standard surgical intervention for UPJO is pyeloplasty, which offers good preservation ...
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