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AuthorSmith S.
AuthorElkashty O.
AuthorTamimi F.
AuthorTran S.D.
AuthorCerruti M.
Available date2022-05-31T19:01:18Z
Publication Date2021
Publication NameLangmuir
ResourceScopus
Identifierhttp://dx.doi.org/10.1021/acs.langmuir.1c01593
URIhttp://hdl.handle.net/10576/31806
AbstractBioactive glasses are surface-reactive glasses that, when placed in physiological fluid, undergo a transformation from glass to hydroxyapatite. Doping the bioactive glass with metallic ions can impart desirable and unique properties that are not inherent to natural hydroxyapatite. Once such ion is titanium. Titanium exists in trace amounts in native dental enamel, and its presence has been correlated with increased tooth hardness and brightness, both desirable clinical properties. Synthetic titanium-substituted hydroxyapatite exhibits better mechanical and antibacterial properties and demonstrates potential for an improved cellular response when compared to unmodified hydroxyapatite with applications in the broader field of bone tissue engineering. In this work, we use the sol-gel method to synthesize a titanium-containing silicate-based bioactive glass aimed at generating titanium-substituted hydroxyapatite on the glass surface upon immersion in body fluid. Titanium is homogeneously distributed throughout our glass, which keeps its amorphous nature. After 14 days of immersion in simulated body fluid, the glass forms a titanium-substituted hydroxyapatite on its surface. Enamel surfaces treated with the titanium-containing glass show significantly increased microhardness compared to enamel surfaces treated with a control glass, confirming the potential for the proposed glass in enamel remineralization. We also show that the presence of titanium in the glass promotes cell differentiation toward bone formation, suggesting further applications for this material in the broader field of bone tissue engineering.
Languageen
PublisherAmerican Chemical Society
SubjectBioactive glass
Body fluids
Bone
Cell engineering
Enamels
Scanning electron microscopy
Silicates
Sol-gel process
Sol-gels
Tissue engineering
Titanium compounds
Bone tissue engineering
Enamel surface
Physiological fluids
Property
Reactive glass
Sol'gel
Substituted hydroxyapatites
Surface treated
Titania
Titanium containing
Hydroxyapatite
glass
hydroxyapatite
silicate
titanium
bone development
Durapatite
Glass
Osteogenesis
Silicates
Titanium
TitleTitanium-Containing Silicate-Based Sol-Gel Bioactive Glass: Development, Characterization, and Applications
TypeArticle
Pagination14243-14253
Issue Number49
Volume Number37
dc.accessType Abstract Only


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