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المؤلفMansour A.
المؤلفAbu Nada L.
المؤلفEl-hadad A.A.
المؤلفMezour M.A.
المؤلفErsheidat A.
المؤلفAl-Subaie A.
المؤلفMoussa H.
المؤلفLaurenti M.
المؤلفKaartinen M.T.
المؤلفTamimi F.
تاريخ الإتاحة2022-05-31T19:01:20Z
تاريخ النشر2021
اسم المنشورJournal of Biomedical Materials Research - Part A
المصدرScopus
المعرّفhttp://dx.doi.org/10.1002/jbm.a.37051
معرّف المصادر الموحدhttp://hdl.handle.net/10576/31820
الملخصThe bone regenerative capacity of synthetic calcium phosphates (CaPs) can be enhanced through the enrichment with selected metal trace ions. However, defining the optimal elemental composition required for bone formation is challenging due to many possible concentrations and combinations of these elements. We hypothesized that the ideal elemental composition exists in the inorganic phase of the bone extracellular matrix (ECM). To study our hypothesis, we first obtained natural hydroxyapatite through the calcination of bovine bone, which was then investigated its reactivity with acidic phosphates to produce CaP cements. Bioceramic scaffolds fabricated using these cements were assessed for their composition, properties, and in vivo regenerative performance and compared with controls. We found that natural hydroxyapatite could react with phosphoric acid to produce CaP cements with biomimetic trace metals. These cements present significantly superior in vivo bone regenerative performance compared with cements prepared using synthetic apatite. In summary, this study opens new avenues for further advancements in the field of CaP bone biomaterials by introducing a simple approach to develop biomimetic CaPs. This work also sheds light on the role of the inorganic phase of bone and its composition in defining the regenerative properties of natural bone xenografts.
اللغةen
الناشرJohn Wiley and Sons Inc
الموضوعBioceramics
Biomimetics
Calcium phosphate
Cements
Hydroxyapatite
Mammals
Phosphate minerals
Bioceramic scaffolds
Bone biomaterials
Elemental compositions
Extracellular matrices
Natural hydroxyapatite
Regenerative capacity
Selected metals
Synthetic apatites
Trace elements
apatite
bioceramics
bone cement
calcium phosphate
calcium phosphate dibasic
carprofen
citric acid
hydroxyapatite
isoflurane
phosphate
phosphoric acid
trace metal
calcium phosphate
calcium phosphate, dibasic, dihydrate
citric acid
metal
phosphoric acid
trace element
animal experiment
Article
biomimetics
bone regeneration
chemical composition
compressive strength
controlled study
crystallography
extracellular matrix
Fourier transform infrared spectroscopy
in vivo study
inductively coupled plasma atomic emission spectrometry
micro-computed tomography
nonhuman
particle size
pH measurement
pneumothorax
postoperative infection
postoperative pain
rat
scanning electron microscopy
animal
bone regeneration
bovine
ceramics
chemistry
diagnostic imaging
drug effect
female
infrared spectroscopy
injury
isolation and purification
materials testing
pharmacology
Sprague Dawley rat
tibia
X ray crystallography
Animals
Biomimetics
Bone Cements
Bone Regeneration
Calcium Phosphates
Cattle
Ceramics
Citric Acid
Compressive Strength
Crystallography, X-Ray
Durapatite
Female
Materials Testing
Metals
Phosphoric Acids
Rats
Rats, Sprague-Dawley
Spectroscopy, Fourier Transform Infrared
Tibia
Trace Elements
X-Ray Microtomography
العنوانBiomimetic trace metals improve bone regenerative properties of calcium phosphate bioceramics
النوعArticle
الصفحات666-681
رقم العدد5
رقم المجلد109
dc.accessType Abstract Only


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