Biomimetic trace metals improve bone regenerative properties of calcium phosphate bioceramics
Author | Mansour A. |
Author | Abu Nada L. |
Author | El-hadad A.A. |
Author | Mezour M.A. |
Author | Ersheidat A. |
Author | Al-Subaie A. |
Author | Moussa H. |
Author | Laurenti M. |
Author | Kaartinen M.T. |
Author | Tamimi F. |
Available date | 2022-05-31T19:01:20Z |
Publication Date | 2021 |
Publication Name | Journal of Biomedical Materials Research - Part A |
Resource | Scopus |
Identifier | http://dx.doi.org/10.1002/jbm.a.37051 |
Abstract | The bone regenerative capacity of synthetic calcium phosphates (CaPs) can be enhanced through the enrichment with selected metal trace ions. However, defining the optimal elemental composition required for bone formation is challenging due to many possible concentrations and combinations of these elements. We hypothesized that the ideal elemental composition exists in the inorganic phase of the bone extracellular matrix (ECM). To study our hypothesis, we first obtained natural hydroxyapatite through the calcination of bovine bone, which was then investigated its reactivity with acidic phosphates to produce CaP cements. Bioceramic scaffolds fabricated using these cements were assessed for their composition, properties, and in vivo regenerative performance and compared with controls. We found that natural hydroxyapatite could react with phosphoric acid to produce CaP cements with biomimetic trace metals. These cements present significantly superior in vivo bone regenerative performance compared with cements prepared using synthetic apatite. In summary, this study opens new avenues for further advancements in the field of CaP bone biomaterials by introducing a simple approach to develop biomimetic CaPs. This work also sheds light on the role of the inorganic phase of bone and its composition in defining the regenerative properties of natural bone xenografts. |
Language | en |
Publisher | John Wiley and Sons Inc |
Subject | Bioceramics Biomimetics Calcium phosphate Cements Hydroxyapatite Mammals Phosphate minerals Bioceramic scaffolds Bone biomaterials Elemental compositions Extracellular matrices Natural hydroxyapatite Regenerative capacity Selected metals Synthetic apatites Trace elements apatite bioceramics bone cement calcium phosphate calcium phosphate dibasic carprofen citric acid hydroxyapatite isoflurane phosphate phosphoric acid trace metal calcium phosphate calcium phosphate, dibasic, dihydrate citric acid metal phosphoric acid trace element animal experiment Article biomimetics bone regeneration chemical composition compressive strength controlled study crystallography extracellular matrix Fourier transform infrared spectroscopy in vivo study inductively coupled plasma atomic emission spectrometry micro-computed tomography nonhuman particle size pH measurement pneumothorax postoperative infection postoperative pain rat scanning electron microscopy animal bone regeneration bovine ceramics chemistry diagnostic imaging drug effect female infrared spectroscopy injury isolation and purification materials testing pharmacology Sprague Dawley rat tibia X ray crystallography Animals Biomimetics Bone Cements Bone Regeneration Calcium Phosphates Cattle Ceramics Citric Acid Compressive Strength Crystallography, X-Ray Durapatite Female Materials Testing Metals Phosphoric Acids Rats Rats, Sprague-Dawley Spectroscopy, Fourier Transform Infrared Tibia Trace Elements X-Ray Microtomography |
Type | Article |
Pagination | 666-681 |
Issue Number | 5 |
Volume Number | 109 |
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