Composition and characteristics of trabecular bone in osteoporosis and osteoarthritis
المؤلف | Tamimi, Iskandar |
المؤلف | Cortes, Arthur Rodríguez González |
المؤلف | Sánchez-Siles, Juan-Manuel |
المؤلف | Ackerman, Jerome L. |
المؤلف | González-Quevedo, David |
المؤلف | García, Ángel |
المؤلف | Yaghoubi, Farid |
المؤلف | Abdallah, Mohamed-Nur |
المؤلف | Eimar, Hazem |
المؤلف | Alsheghri, Ammar |
المؤلف | Laurenti, Marco |
المؤلف | Al-Subaei, Ahmad |
المؤلف | Guerado, Enrique |
المؤلف | García-de-Quevedo, David |
المؤلف | Tamimi, Faleh |
تاريخ الإتاحة | 2022-05-31T19:01:22Z |
تاريخ النشر | 2020 |
اسم المنشور | Bone |
المصدر | Scopus |
المعرّف | http://dx.doi.org/10.1016/j.bone.2020.115558 |
الملخص | Background Bone strength depends on multiple factors such as bone density, architecture and composition turnover. However, the role these factors play in osteoporotic fractures is not well understood. Purpose The aim of this study was to analyze trabecular bone architecture, and its crystal and organic composition in humans, by comparing samples taken from patients who had a hip fracture (HF) and individuals with hip osteoarthritis (HOA). Methods The study included 31 HF patients and 42 cases of HOA who underwent joint replacement surgery between 1/1/2013 and 31/12/2013. Trabecular bone samples were collected from the femoral heads and analyzed using a dual-energy X-ray absorptiometry, micro-CT, and solid-state high-resolution magic-angle-spinning nuclear magnetic resonance (MAS-NMR) spectroscopy. Results No differences in proton or phosphorus concentration were found between the two groups using 1H single pulse, 31P single pulse, 31P single pulse with proton decoupling NMR spectroscopy, in hydroxyapatite (HA) c-axis or a-axis crystal length. Bone volume fraction (BV/TV), trabecular number (Tb.N), and bone mineral density (BMD) were higher in the HO group than in the HF group [28.6% ± 10.5 vs 20.3% ± 6.6 (p = 0.026); 2.58 mm−1 ± 1.57 vs 1.5 mm−1 ± 0.79 (p = 0.005); and 0.39 g/cm2 ± 0.10 vs. 0.28 g/cm2 ± 0.05 (p = 0.002), respectively]. The trabecular separation (Tp.Sp) was lower in the HO group 0.42 mm ± 0.23 compared with the HF group 0.58 mm ± 0.27 (p = 0.036). In the HO group, BMD was correlated with BV/TV (r = 0.704, p < 0.001), BMC (r = 0.853, p < 0.001), Tb.N (r = 0.653, p < 0.001), Tb.Sp (−0.561, p < 0.001) and 1H concentration (−0.580, p < 0.001) in the HO group. BMD was not correlated with BV/TV, Tb.Sp, Tb.Th, Tb.N, Tb.PF, 1H concentration or HA crystal size in the HF group. Conclusions Patients with HO who did not sustain previous hip fractures had a higher femoral head BMD, BV/TV, and Tb.N than HF patients. In HO patients, BMD was positively correlated with the BV/TV and Tb.N and negatively correlated with the femoral head organic content and trabecular separation. Interestingly, these correlations were not found in HF patients with relatively lower bone densities. Therefore, osteoporotic patients with similar low bone densities could have significant microstructural differences. No differences were found between the two groups at a HA crystal level. |
اللغة | en |
الناشر | Elsevier Inc. |
الموضوع | hydroxyapatite phosphorus phosphorus 31 proton adult aged Article bone densitometry bone density bone level bone structure bone volume fraction chemical composition controlled study correlation analysis crystal structure dual energy X ray absorptiometry female femoral head hip fracture hip osteoarthritis human human tissue major clinical study male micro-computed tomography musculoskeletal system parameters nuclear magnetic resonance spectroscopy osteoporosis particle size photon replacement arthroplasty trabecular bone diagnostic imaging osteoarthritis osteoporosis photon absorptiometry trabecular bone Absorptiometry, Photon Bone Density Cancellous Bone Humans Osteoarthritis Osteoporosis |
النوع | Article |
رقم المجلد | 140 |
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