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AuthorTamimi F.
AuthorAbusamak M.
AuthorAkkanti B.
AuthorChen Z.
AuthorYoo S.-H.
AuthorKarmouty-Quintana H.
Available date2022-05-31T19:01:22Z
Publication Date2020
Publication NameBritish Journal of Pharmacology
ResourceScopus
Identifierhttp://dx.doi.org/10.1111/bph.15140
URIhttp://hdl.handle.net/10576/31830
AbstractCoronavirus disease 2019 (COVID-19), the disease resulting from infection by a novel coronavirus, SARS-Cov2, has rapidly spread since November 2019 leading to a global pandemic. SARS-Cov2 has infected over four million people and caused over 290,000 deaths worldwide. Although most cases are mild, a subset of patients develop a severe and atypical presentation of acute respiratory distress syndrome (ARDS) that is characterised by a cytokine release storm (CRS). Paradoxically, treatment with anti-inflammatory agents and immune regulators has been associated with worsening of ARDS. We hypothesize that the intrinsic circadian clock of the lung and the immune system may regulate individual components of CRS, and thus, chronotherapy may be used to effectively manage ARDS in COVID-19 patients. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID-19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/http://dx.doi.org/10.1111/bph.v177.21/issuetoc.
Languageen
PublisherJohn Wiley and Sons Inc
SubjectCXCL1 chemokine
ibuprofen
interleukin 12
interleukin 1beta
interleukin 6
monocyte chemotactic protein 1
nuclear receptor NR1D1
PER2 protein
RANTES
toll like receptor 4
toll like receptor 9
transcription factor ARNTL
transcription factor CLOCK
antiinflammatory agent
adult respiratory distress syndrome
artificial ventilation
asthma
bronchiolitis
chronotherapy
circadian rhythm
coronavirus disease 2019
cytokine storm
epidemic
human
hypophysis adrenal system
immune system
lung parenchyma
nonhuman
patient care
priority journal
protein expression
respiratory system
Review
Severe acute respiratory syndrome coronavirus 2
virus pneumonia
adult respiratory distress syndrome
animal
Betacoronavirus
chronopharmacology
Coronavirus infection
cytokine release syndrome
immunology
isolation and purification
pandemic
physiology
virology
virus pneumonia
Animals
Anti-Inflammatory Agents
Betacoronavirus
Circadian Rhythm
Coronavirus Infections
Cytokine Release Syndrome
Drug Chronotherapy
Humans
Pandemics
Pneumonia, Viral
Respiratory Distress Syndrome, Adult
TitleThe case for chronotherapy in Covid-19-induced acute respiratory distress syndrome
TypeArticle
Pagination4845-4850
Issue Number21
Volume Number177
dc.accessType Abstract Only


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