تصفح Faculty Contributions حسب الموضوع "DNA methylation"
السجلات المعروضة 1 -- 8 من 8
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Characterization of regulatory sequences in alternative promoters of hypermethylated genes associated with tumor resistance to cisplatin
( Spandidos Publications , 2014 , Article)The development of cisplatin resistance in human cancers is controlled by multiple genes and leads to therapeutic failure. Hypermethylation of specific gene promoters is a key event in clinical resistance to cisplatin. ... -
Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway
( Elsevier , 2020 , Article)Compelling evidence has demonstrated that tumor bulk comprises distinctive subset of cells generally referred as cancer stem cells (CSCs) that has been proposed as a strong sustainer and promoter of tumorigenesis and ... -
Genomic and Bioinformatics Approaches for Analysis of Genes Associated With Cancer Risks Following Exposure to Tobacco Smoking
( Frontiers Media S.A. , 2018 , Article Review)Cancer is a significant health problem in the Middle East and global population. It is well established that there is a direct link between tobacco smoking and cancer, which will continue to pose a significant threat to ... -
Glucocorticoid-induced fetal origins of adult hypertension: Association with epigenetic events
( Elsevier Inc. , 2016 , Article Review)Hypertension is a predominant risk factor for cardiovascular diseases and a major health care burden. Accumulating epidemiological and experimental evidence suggest that adult-onset hypertension may have its origins during ... -
Immunomodulatory Properties of Human Breast Milk: MicroRNA Contents and Potential Epigenetic Effects
( MDPI , 2022 , Article)Infants who are exclusively breastfed in the first six months of age receive adequate nutrients, achieving optimal immune protection and growth. In addition to the known nutritional components of human breast milk (HBM), ... -
Increased de novo DNA methylation enzymes in sperm of individuals with varicocele
( pmc , 2021 , Article)Objective: Chronic genital heat-stress associated with varicocele leads to DNA hypo-methylation of spermatozoa. The objective of this study was comparing level of DNA methyl-transferases (DNMTs) in sperm of men suffering ... -
Mendelian inheritance of trimodal CpG methylation sites suggests distal cis-acting genetic effects.
( BioMed Central , 2016 , Article)Environmentally influenced phenotypes, such as obesity and insulin resistance, can be transmitted over multiple generations. Epigenetic modifications, such as methylation of DNA cytosine-guanine (CpG) pairs, may be carriers ... -
WNT5A, β‑catenin and SUFU expression patterns, and the significance of microRNA deregulation in placentas with intrauterine growth restriction
( Spandidos Publications , 2023 , Article)Placental insufficiency is a common cause of intrauterine growth restriction (IUGR). It affects ~10% of pregnancies and increases fetal and neonatal morbidity and mortality. Although Wnt and Hh pathways are crucial for ...