Browsing Faculty Contributions by Subject "Ubiquitin"

Now showing items 1-3 of 3

Detection of β-Arrestin-Mediated G Protein-Coupled Receptor Ubiquitination Using BRET.

Nagi, Karim; Shenoy, Sudha K ( Humana Press, New York, NY , 2019 , Book chapter)
Ubiquitination of G protein-coupled receptors (GPCRs) is an important dynamic posttranslational modification that has been linked to the intracellular trafficking of internalized GPCRs to lysosomes. Ubiquitination of GPCRs ...
In-frame fusion of SUMO1 enhances βarrestin2's association with activated GPCRs as well as with nuclear pore complexes

Karim, Nagi; Kaur, Suneet; Bai, Yushi; Shenoy, Sudha K. ( Elsevier , 2020 , Article)
Small ubiquitin like modifier (SUMO) conjugation or SUMOylation of βarrestin2 promotes its association with the clathrin adaptor protein AP2 and facilitates rapid β2 adrenergic receptor (β2AR) internalization. However, ...
TRAF6-mediated ubiquitination of NEMO requires p62/sequestosome-1

Zotti, Tiziana; Scudiero, Ivan; Settembre, Pio; Ferravante, Angela; Mazzone, Pellegrino; D'Andrea, Luca; Reale, Carla; Vito, Pasquale; Stilo, Romania... more authors ... less authors ( Elsevier Ltd , 2014 , Article)
The atypical protein kinase C-interacting protein p62/sequestosome-1 (p62) has emerged as a crucial molecule in a variety of cellular functions due to its involvement in various signaling mechanisms. p62 has been implicated ...