Search
Now showing items 21-30 of 32
Influenza prevalence and vaccine efficacy among diabetic patients in Qatar
(
Elsevier
, 2023 , Article)
Seasonal influenza viruses may lead to severe illness and mortality in patients with comorbidities, including Diabetes Mellitus (DM). Vaccination against influenza in DM patients may reduce influenza incidence and severity. ...
Metformin and HER2-positive breast cancer: Mechanisms and therapeutic implications
(
Elsevier
, 2023 , Article)
Due to the strong association between diabetes and cancer incidents, several anti-diabetic drugs, including metformin, have been examined for their anticancer activity. Metformin is a biguanide antihyperglycemic agent used ...
Effect of lifestyle intervention on HbA1c levels in overweight and obese adults with type 2 diabetes across ethnicities: A systematic review and meta-analysis of randomized controlled trials
(
Elsevier
, 2023 , Article)
AimsWeight reduction is fundamental for the management and remission of diabetes. We aimed to assess ethnic differences in the effects of lifestyle weight-loss interventions on HbA1c levels in overweight or obese adults ...
Potential causes of male and female infertility in Qatar
(
Elsevier
, 2020 , Article Review)
A steady decline in the fertility rate has been observed in Qatar during the past fifty years. Therefore, infertility is considered a national priority in Qatar, a pronatalist society. This review article summarises the ...
Protein glycation – biomarkers of metabolic dysfunction and early-stage decline in health in the era of precision medicine
(
Elsevier
, 2021 , Article)
Protein glycation provides a biomarker in widespread clinical use, glycated hemoglobin HbA1c (A1C). It is a biomarker for diagnosis of diabetes and prediabetes and of medium-term glycemic control in patients with established ...
Hexokinase-2-Linked Glycolytic Overload and Unscheduled Glycolysis—Driver of Insulin Resistance and Development of Vascular Complications of Diabetes
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2022 , Article)
The recent discovery of the glucose-induced stabilization of hexokinase-2 (HK2) to proteolysis in cell dysfunction in model hyperglycemia has revealed a likely key initiating factor contributing to the development of insulin ...
Estimating Blood Glucose Levels Using Machine Learning Models with Non-Invasive Wearable Device Data
(
IOS Press BV
, 2023 , Conference Paper)
In 2019 alone, Diabetes Mellitus impacted 463 million individuals worldwide. Blood glucose levels (BGL) are often monitored via invasive techniques as part of routine protocols. Recently, AI-based approaches have shown the ...
Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2022 , Article)
The abnormal accumulation of methylglyoxal (MG) leading to increased glycation of protein and DNA has emerged as an important metabolic stress, dicarbonyl stress, linked to aging, and disease. Increased MG glycation produces ...
The association between screen time and depression symptoms severity among adults with diabetes: A cross-sectional study
(
Elsevier
, 2023 , Article)
ObjectiveTo investigate the association between time spent on screen-based sedentary behavior (SBSB) and depression symptom severity (DSS) among adults with type 2 diabetes. MethodsA cross-sectional study employing secondary ...
Thromboxane biosynthesis and future events in diabetes: the ASCEND trial
(
Oxford University Press
, 2024 , Article)
Background and Thromboxane (TX) A2, released by activated platelets, plays an important role in atherothrombosis. Urinary 11-dehydro-Aims TXB2 (U-TXM), a stable metabolite reflecting the whole-body TXA2 biosynthesis, is ...