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Now showing items 11941-11950 of 12413
Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria
(
Portland Press Ltd
, 2024 , Article)
Homocystinuria is a rare disease caused by mutations in the CBS gene that results in a deficiency of cystathionine β-synthase (CBS). CBS is an essential pyridoxal 50-phosphate (PLP)-dependent enzyme in the transsulfuration ...
Circadian Syndrome Is Associated with Dietary Patterns among Middle-Older Americans: The Health and Retirement Study
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2024 , Article)
Population aging is a global demographic characteristic of the 21st century, and healthy eating is a core component of healthy aging. However, limited evidence is available among older adults for associations between diet ...
Effectiveness of locally produced ready-to-use supplementary foods on the prevention of stunting in children aged 6-23 months: A community-based trial from Pakistan
(
Cambridge University Press
, 2023 , Article)
Undernutrition is a major public health problem in developing countries. Around 40·2 % of children are stunted in Pakistan. This longitudinal study aimed to assess the effectiveness of locally produced ready-to-use ...
BRCA1 and Its Vulnerable C-Terminal BRCT Domain: Structure, Function, Genetic Mutations and Links to Diagnosis and Treatment of Breast and Ovarian Cancer
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2024 , Article)
The BRCA1 is a tumor suppressor gene that encodes for the BRCA1 protein, which plays a vital role in DNA repair, cell cycle regulation, and the maintenance of genomic stability. The BRCA1 protein interacts with a variety ...
Nrf-2-dependent antioxidant and anti-inflammatory effects underlie the protective effect of esculeoside A against retinal damage in streptozotocin-induced diabetic rats
(
Elsevier
, 2024 , Article)
Esculeoside A (ESA) is a tomato-derived glycoside with antioxidant and anti-inflammatory properties. The protective effect of ESA against diabetic retinopathy is not well-investigated and was the core objective of this ...
Cranial measurements obtained by three-dimensional computed tomography technique in the estimation of sex of contemporary Black South Africans
(
Elsevier
, 2024 , Article)
Human identification forms an integral part of forensic and biological anthropology. For proper identification, a biological profile made up of biodata such as age, sex, ancestry, antemortem stature, and factors of ...
2D magnesium phosphate resorbable coating to enhance cell adhesion on titanium surfaces
(2024 , Article)
Titanium and its alloys are essential metals for orthopedic implant manufacturing due to their exceptional mechanical properties and biocompatibility, used extensively for treating various orthopedic conditions. However, ...
Ether, sulfide and sulfone derivatives of cinnamaldehyde: Insights into synthesis, structural elucidation and solvatochromism
(
Elsevier
, 2024 , Article)
Symmetric ether, sulfide and sulfone derivatives based on Schiff base functionalized group (3a-c) were synthesized via classical condensation of 4,4′-diaminodiphenyl precursors (1a-c) and cinnamaldehyde (2) in methanol at ...
Pharmacy Students’ Perception of the Content and Delivery of Drug Information Training: A Mixed-Methods Study
(
Elsevier
, 2024 , Article)
Objective: To explore the pharmacy students’ perception of the content and pedagogical strategies used for the delivery of drug information (DI) training. Methods: An explanatory sequential mixed-methods study was conducted ...
Bariatric Surgery Improves Serum CD40L Levels as a Predictor of Cardiovascular Risk: Systematic Review and Meta-analysis
(2024 , Article)
CD40 and its ligand have been recently implicated in the pathogenesis of cardiovascular disease (CVD). This meta-analysis examined the effect of bariatric surgery in reducing circulating CD40L levels. A systematic review ...