بحث بسيط
السجلات المعروضة 41 -- 50 من 57
Voltage dependence of the Ca2+ transient in endocardial and epicardial myocytes from the left ventricle of Goto Kakizaki type 2 diabetic rats
(
Springer New York LLC
, 2018 , Article)
Diabetes mellitus is a major global health disorder and, currently, over 450 million people have diabetes with 90% suffering from type 2 diabetes. Left untreated, diabetes may lead to cardiovascular diseases which are a ...
Influenza prevalence and vaccine efficacy among diabetic patients in Qatar
(
Elsevier
, 2023 , Article)
Seasonal influenza viruses may lead to severe illness and mortality in patients with comorbidities, including Diabetes Mellitus (DM). Vaccination against influenza in DM patients may reduce influenza incidence and severity. ...
Metformin and HER2-positive breast cancer: Mechanisms and therapeutic implications
(
Elsevier
, 2023 , Article)
Due to the strong association between diabetes and cancer incidents, several anti-diabetic drugs, including metformin, have been examined for their anticancer activity. Metformin is a biguanide antihyperglycemic agent used ...
Effect of lifestyle intervention on HbA1c levels in overweight and obese adults with type 2 diabetes across ethnicities: A systematic review and meta-analysis of randomized controlled trials
(
Elsevier
, 2023 , Article)
AimsWeight reduction is fundamental for the management and remission of diabetes. We aimed to assess ethnic differences in the effects of lifestyle weight-loss interventions on HbA1c levels in overweight or obese adults ...
Protein glycation – biomarkers of metabolic dysfunction and early-stage decline in health in the era of precision medicine
(
Elsevier
, 2021 , Article)
Protein glycation provides a biomarker in widespread clinical use, glycated hemoglobin HbA1c (A1C). It is a biomarker for diagnosis of diabetes and prediabetes and of medium-term glycemic control in patients with established ...
Postprandial insulin and triglyceride concentrations are suppressed in response to breaking up prolonged sitting in Qatari females
(
Frontiers Media S.A.
, 2019 , Article)
Background: Cultural, environmental and logistical factors challenge the Qatari population, particularly females, to engage in physical activity, and there is a high prevalence of diabetes in this population. Sedentary ...
Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes
(
Elsevier
, 2023 , Article)
AimCardiac autonomic neuropathy (CAN) has been suggested to be associated with hypoglycemia and impaired hypoglycemia unawareness. We have assessed the relationship between CAN and extensive measures of glucose variability ...
Clinical characteristics of 51,815 patients presenting with positive and negative SARS-CoV-2 swab results in primary health care settings: Priority populations for vaccination
(
Elsevier
, 2021 , Article)
We read with interest Brendish et al. study on the comparison between patients with SARS-CoV-2 positive and negative swab results.1
The study compared the clinical characteristics of adult hospitalised patients with ...
Hexokinase-2-Linked Glycolytic Overload and Unscheduled Glycolysis—Driver of Insulin Resistance and Development of Vascular Complications of Diabetes
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2022 , Article)
The recent discovery of the glucose-induced stabilization of hexokinase-2 (HK2) to proteolysis in cell dysfunction in model hyperglycemia has revealed a likely key initiating factor contributing to the development of insulin ...
Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2022 , Article)
The abnormal accumulation of methylglyoxal (MG) leading to increased glycation of protein and DNA has emerged as an important metabolic stress, dicarbonyl stress, linked to aging, and disease. Increased MG glycation produces ...