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Locality Sensitive Deep Learning for Detection and Classification of Nuclei in Routine Colon Cancer Histology Images
(
Institute of Electrical and Electronics Engineers Inc.
, 2016 , Article)
Detection and classification of cell nuclei in histopathology images of cancerous tissue stained with the standard hematoxylin and eosin stain is a challenging task due to cellular heterogeneity. Deep learning approaches ...
25-Hydroxyvitamin D Concentrations and Clostridium difficile Infection: A Meta-Analysis
(
SAGE Publications Inc.
, 2017 , Article)
Background: Well-known risk factors for Clostridium difficile infection (CDI) are exposure to antibiotics and gastric acid suppressants. Recent studies have provided some evidence of an association between hypovitaminosis ...
Patient-Specific Seizure Detection Using Nonlinear Dynamics and Nullclines
(
Institute of Electrical and Electronics Engineers Inc.
, 2020 , Article)
Nonlinear dynamics has recently been extensively used to study epilepsy due to the complex nature of the neuronal systems. This study presents a novel method that characterizes the dynamic behavior of pediatric seizure ...
Generation of gene edited hiPSC from familial Alzheimer's disease patient carrying N141I missense mutation in presenilin 2
(
Elsevier B.V.
, 2021 , Article)
Alzheimer's disease (AD) is the major cause of dementia worldwide. Early-onset familial AD accounts for about 0.5% of all AD and is caused by single major gene mutations and autosomal dominant inheritance. An N141I missense ...
Osseointegration Pharmacology: A Systematic Mapping Using Artificial Intelligence
(
Acta Materialia Inc
, 2021 , Article)
Clinical performance of osseointegrated implants could be compromised by the medications taken by patients. The effect of a specific medication on osseointegration can be easily investigated using traditional systematic ...
Is there truly an increase in risk of cardiovascular and hematological adverse events with vascular endothelial growth factor receptor tyrosine kinase inhibitors?
(
Taylor and Francis Ltd
, 2020 , Article)
Objectives: Recent studies have shown an increase risk of cardiovascular and hematological adverse events associated with vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs). The authors hypothesize ...
Needle-free Mental Incisive Nerve Block: In vitro, Cadaveric, and Pilot Clinical Studies
(
Elsevier B.V.
, 2021 , Article)
The present study aimed to optimize Needle-Free Liquid Jet Injection (NFLJI) for Mental Incisive Nerve Blocks (MINB) and evaluate its clinical safety and feasibility. A MINB protocol was developed and optimized by series ...
COVID-19 infection localization and severity grading from chest X-ray images
(
Elsevier Ltd
, 2021 , Article)
The immense spread of coronavirus disease 2019 (COVID-19) has left healthcare systems incapable to diagnose and test patients at the required rate. Given the effects of COVID-19 on pulmonary tissues, chest radiographic ...
Composition and characteristics of trabecular bone in osteoporosis and osteoarthritis
(
Elsevier Inc.
, 2020 , Article)
Background
Bone strength depends on multiple factors such as bone density, architecture and composition turnover. However, the role these factors play in osteoporotic fractures is not well understood.
Purpose
The aim ...
Design and synthesis of novel chalcones as potent selective monoamine oxidase-B inhibitors
(
Elsevier Masson SAS
, 2016 , Article)
A novel series of substituted chalcones were designed and synthesized to be evaluated as selective human MAO-B inhibitors. A combination of either methylsulfonyl or trifluoromethyl substituents on the aromatic ketone moiety ...