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Umbelliferone inhibits spermatogenic defects and testicular injury in lead-intoxicated rats by suppressing oxidative stress and inflammation, and improving Nrf2/HO-1 signaling
(
Dove Medical Press
, 2020 , Article)
© 2020 Alotaibi et al. Introduction: Lead (Pb) is an environmental toxic metal that threatens human health. Umbelliferone (UMB) is a coumarin with known medicinal and protective properties against cytotoxicity. This study ...
Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II
(
Frontiers Media
, 2016 , Article)
Traditional medicine has a history extending back to thousands of years, and during the intervening time, man has identified the healing properties of a very broad range of plants. Globally, the use of herbal therapies to ...
The neuroprotective effect of vitamin E on waterpipe tobacco smoking-induced memory impairment: The antioxidative role
(
Elsevier Inc.
, 2019 , Article)
Aims: Tobacco smoking is associated with a vast range of adverse health effects, including diminished cognitive and anti-oxidative capabilities. Conversely, vitamin E (VitE) is known to enhance data acquisition and retention ...
Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress
(
Elsevier B.V.
, 2016 , Article)
Mitochondria are important for providing cellular energy ATP through the oxidative phosphorylation pathway. They are also critical in regulating many cellular functions including the fatty acid oxidation, the metabolism ...
The 4-hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions
(
Spandidos Publications
, 2018 , Article)
Lipid peroxidation is associated with several metabolic diseases. Lipid peroxidation causes cellular damage through reactive aldehyde species such as 4-hydroxyonenal (4-HNE). The exact mechanism(s) by which 4-HNE causes ...
A potential link between oxidative stress and endothelial-to-mesenchymal transition in systemic sclerosis
(
Frontiers Media S.A.
, 2018 , Article Review)
Systemic sclerosis (SSc), an autoimmune disease that is associated with a number of genetic and environmental risk factors, is characterized by progressive fibrosis and microvasculature damage in the skin, lungs, heart, ...
Withania somnifera root powder protects againist post-traumatic stress disorder-induced memory impairment
(
Springer Netherlands
, 2019 , Article)
Post-traumatic stress disorder (PTSD) is precipitated by exposure to severe traumatic events such as wars, natural disasters, catastrophes, or other traumatic events. Withania somnifera (WS) Dunal (family: Solanaceae) known ...
Impact of physical exercise on gut microbiome, inflammation, and the pathobiology of metabolic disorders
(
Society for Biomedical Diabetes Research
, 2019 , Article)
BACKGROUND: The gastrointestinal tract (GIT) harbors a complex and diverse microbial composition that outnumbers our own body cells and their gene contents. These microbes play a significant role in host metabolism and ...
Oxidative stress cytotoxicity induced by platinum-doped magnesia nanoparticles in cancer cells
(
Elsevier
, 2021 , Article)
The aim of this study was to prepare, characterize, and determine the in vitro anticancer effects of platinum-doped magnesia (Pt/MgO) nanoparticles. The chemical compositions, functional groups, and size of nanoparticles ...
Anti-hypertensive Herbs and their Mechanisms of Action: Part I
(
Frontiers Media
, 2016 , Article)
The use of herbal therapies for treatment and management of cardiovascular diseases (CVDs) is increasing. Plants contain a bounty of phytochemicals that have proven to be protective by reducing the risk of various ailments ...