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Endoplasmic Reticulum Stress: A Critical Molecular Driver of Endothelial Dysfunction and Cardiovascular Disturbances Associated with Diabetes.
(
MDPI
, 2019 , Article)
Physical inactivity and sedentary lifestyle contribute to the widespread epidemic of obesity among both adults and children leading to rising cases of diabetes. Cardiovascular disease complications associated with obesity ...
Crosstalk Between Oxidative Stress and Endoplasmic Reticulum (ER) Stress in Endothelial Dysfunction and Aberrant Angiogenesis Associated With Diabetes: A Focus on the Protective Roles of Heme Oxygenase (HO)-1
(
Frontiers Media
, 2019 , Article Review)
Type-2 diabetes prevalence is continuing to rise worldwide due to physical inactivity and obesity epidemic. Diabetes and fluctuations of blood sugar are related to multiple micro- and macrovascular complications, that are ...
High Selenium Intake is Associated with Endothelial Dysfunction: Critical Role for Endoplasmic Reticulum Stress
(
Hamad bin Khalifa University Press (HBKU Press)
, 2016 , Conference Paper)
Selenium is associated with insulin resistance and may therefore affect endothelial function, increasing type II diabetes risk and associated cardiovascular-disease risk. However the underpinning molecular mechanisms ...
Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium
(
Wiley
, 2020 , Article)
Selenium is an essential trace element important for human health. A balanced intake is, however, crucial to maximize the health benefits of selenium. At physiological concentrations, selenium mediates antioxidant, ...
Heme oxygenase (HO)-1 induction prevents Endoplasmic Reticulum stress-mediated endothelial cell death and impaired angiogenic capacity
(
Elsevier
, 2016 , Article)
Most of diabetic cardiovascular complications are attributed to endothelial dysfunction and impaired angiogenesis. Endoplasmic Reticulum (ER) and oxidative stresses were shown to play a pivotal role in the development of ...