Search
Now showing items 1-3 of 3
Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.
(
BMC
, 2020 , Article)
Recent studies indicated that seeded fibril formation and toxicity of α-synuclein (α-syn) play a main role in the pathogenesis of certain diseases including Parkinson's disease (PD), multiple system atrophy, and dementia ...
Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease
(
BioMed Central
, 2016 , Article)
Background
Despite decades of intensive research, to date, there is no accepted diagnosis for Parkinson’s disease (PD) based on biochemical analysis of blood or CSF. However, neurodegeneration in the brains of PD patients ...
Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit in-vitro seeded aggregation and toxicity.
(
FEBS PRESS
, 2022 , Article)
Nanobodies (Nbs), the single-domain antigen-binding fragments of dromedary heavy-chain antibodies (HCAb), are excellent candidates as therapeutic and diagnostic tools in synucleinopathies because of their small size, ...