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The Role of Protein Tyrosine Phosphatase (PTP)-1B in Cardiovascular Disease and Its Interplay with Insulin Resistance.
(
MDPI
, 2019 , Article Review)
Endothelial dysfunction is a key feature of cardiovascular disorders associated with obesity and diabetes. Several studies identified protein tyrosine phosphatase (PTP)-1B, a member of the PTP superfamily, as a major ...
The impact of health status, diet and lifestyle on non-alcoholic fatty liver disease: Narrative review
(
Wiley
, 2022 , Article Review)
Non-alcoholic fatty liver disease (NAFLD) is defined as the abnormal accumulation of triglycerides in the liver. NAFLD has a global prevalence of almost 30%, while incidence is rising with increasing levels of obesity, ...
Pharmacotherapy in COVID-19 patients: a review of ACE2-raising drugs and their clinical safety
(
Taylor and Francis Ltd
, 2020 , Article Review)
The COVID-19 pandemic is caused by the severe acute-respiratory-syndrome-coronavirus-2 that uses ACE2 as its receptor. Drugs that raise serum/tissue ACE2 levels include ACE inhibitors (ACEIs) and angiotensin-II receptor ...
The effect of nuts consumption on circulating oxidized low-density lipoproteins: A systematic review and meta-analysis of randomized controlled trials.
(
Wiley
, 2023 , Article Review)
This systematic review and meta-analysis evaluated the effect of nuts in decreasing circulating levels of oxidized low-density lipoproteins (ox-LDL). A literature search was performed of major electronic databases ...
Inflammation and hypertension: Underlying mechanisms and emerging understandings
(
wiley online library
, 2023 , Article Review)
Hypertension remains a major contributor to cardiovascular disease (CVD), a leading cause of global death. One of the major insults that drive increased blood pressure is inflammation. While it is the body's defensive ...
The pleiotropic effects of antithrombotic drugs in the metabolic-cardiovascular-neurodegenerative disease continuum: Impact beyond reduced clotting
(
Portland Press Ltd
, 2021 , Article Review)
Antithrombotic drugs are widely used for primary and secondary prevention, as well as treatment of many cardiovascular disorders. Over the past few decades, major advances in the pharmacology of these agents have been made ...
Flavonoids in adipose tissue inflammation and atherosclerosis: One arrow, two targets
(
Portland Press Ltd
, 2020 , Article Review)
Flavonoids are polyphenolic compounds naturally occurring in fruits and vegetables, in addition to beverages such as tea and coffee. Flavonoids are emerging as potent therapeutic agents for cardiovascular as well as metabolic ...
Infection with Helicobacter pylori may predispose to atherosclerosis: role of inflammation and thickening of intima-media of carotid arteries
(
Frontiers Media
, 2023 , Article Review)
Atherosclerosis is a major instigator of cardiovascular disease (CVD) and a main cause of global morbidity and mortality. The high prevalence of CVD calls for urgent attention to possible preventive measures in order to ...
Impact of the MIF -173G/C variant on cardiovascular disease risk: a meta-analysis of 9,047 participants
(
Frontiers Media SA
, 2024 , Article Review)
Introduction: Many factors contribute to the risk of cardiovascular disease (CVD), an umbrella term for several different heart diseases, including inflammation. Macrophage migration inhibitory factor (MIF) is an important ...