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AMP-activated protein kinase as a drug target in chronic kidney disease
(
Bentham Science Publishers B.V.
, 2018 , Article Review)
Background: Chronic kidney disease (CKD) is a condition increasingly affecting millions of individuals worldwide and is ranked as the ninth leading cause of death in the United States. AMP-activated protein kinase (AMPK) ...
Cisplatin based therapy: The role of the mitogen activated protein kinase signaling pathway
(
BioMed Central Ltd.
, 2018 , Article Review)
Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers. However, treatment with cisplatin is associated with drug resistance and several adverse side effects such as nephrotoxicity, reduced ...
Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis.
(
Springer
, 2020 , Article Review)
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an abnormal fibrotic response involving vast ...
Role of RhoA and Rho-associated kinase in phenotypic switching of vascular smooth muscle cells: Implications for vascular function
(
Elsevier
, 2022 , Article Review)
Cardiovascular disease (CVD) continues to be the primary cause of global mortality. Vascular smooth muscle cells (VSMCs) are integral components of vascular structure and function, evident by their vital roles in modulating ...
Deregulation of cell growth and apoptosis in UV-induced melanomagenesis
(
Frontiers in Bioscience
, 2020 , Article Review)
We have previously characterized the role of p16/Rb in coordinating the early events in UVB-irradiated skin. As an extension to this work, normal melanocytes and mutant p16-inducible melanoma cell models were employed to ...
An updated overview of cyanidins for chemoprevention and cancer therapy
(
Elsevier
, 2023 , Article Review)
Anthocyanins are colored polyphenolic compounds that belong to the flavonoids family and are largely present in many vegetables and fruits. They have been used in traditional medicine in many cultures for a long time. The ...
Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents
(
Elsevier
, 2022 , Article Review)
Cancer is one of the leading causes of death and significantly burdens the healthcare system. Due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. The use of natural products as ...
MDM2- an indispensable player in tumorigenesis
(
Springer Science and Business Media B.V.
, 2023 , Article Review)
Murine double minute 2 (MDM2) is a well-recognized molecule for its oncogenic potential. Since its identification, various cancer-promoting roles of MDM2 such as growth stimulation, sustained angiogenesis, metabolic ...