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Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms

Anwar-Mohamed, Anwar; Elshenawy, Osama H.; Soshilov, Anatoly A.; Denison, Michael S.; Le, X. Chris; ... more authors ... less authors ( Elsevier Inc. , 2014 , Article)

Activation of the aryl hydrocarbon receptor (AhR) ultimately leads to the induction of the carcinogen-activating enzyme cytochrome P450 1A1 (CYP1A1), and activation of the nuclear factor-erythroid 2 p45-related factor 2 ...