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    A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation causing breast cancer. 

    Thirumal Kumar, D; Jain, Nikita; Evangeline, Judith; Kamaraj, Balu; Siva, R; Zayed, Hatem; George Priya Doss, C... more authors ... less authors ( Elsevier , 2019 , Article)
    Breast cancer (BC) is the most commonly diagnosed cancer among females worldwide, and among the BC-associated mutations in various proteins, mutations in the RAC-alpha serine/threonine-protein kinase (AKT1) remain the most ...
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    Understanding the structure-function relationship of HPRT1 missense mutations in association with Lesch-Nyhan disease and HPRT1-related gout by in silico mutational analysis. 

    Agrahari, Ashish Kumar; Krishna Priya, M; Praveen Kumar, Medapalli; Tayubi, Iftikhar Aslam; Siva, R; Prabhu Christopher, B; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Elsevier , 2019 , Article)
    The nucleotide salvage pathway is used to recycle degraded nucleotides (purines and pyrimidines); one of the enzymes that helps to recycle purines is hypoxanthine guanine phosphoribosyl transferase 1 (HGPRT1). Therefore, ...
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    Association of genetic variants with colorectal cancer in the extended MENA region: A systematic review 

    Sidenna, Mariem; Bux, Reem; Fadl, Tasnim; Ozbek, Ugur; Zayed, Hatem ( Bentham Science Publishers , 2019 , Article)
    Colorectal cancer (CRC) is the third most common cancer worldwide and the third leading cause of cancer-related death. It is a heterogeneous disease that develops through different genetic and epigenetic mechanisms. To ...
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    Molecular insights of the G2019S substitution in LRRK2 kinase domain associated with Parkinson's disease: A molecular dynamics simulation approach. 

    Agrahari, Ashish Kumar; Doss, George Priya C; Siva, R; Magesh, R; Zayed, Hatem ( Elsevier , 2019 , Article)
    The G2019S substitution in the Leucine-rich repeat kinase 2 (LRRK2) is significantly associated with Parkinson's disease (PD). This substitution was identified in both familial and sporadic forms of PD with a higher ...
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    Genetic epidemiology of ovarian cancer in the 22 Arab countries: A systematic review. 

    Younes, Nadin; Zayed, Hatem ( Elsevier , 2019 , Article)
    Ovarian cancer (OC) is a common disease among Arabs, with one of the highest incidences in the world. OC is underdiagnosed, underreported, and mostly reported with breast cancer. This study aimed to conduct a systematic ...
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    Identification of potential inhibitors against pathogenic missense mutations of PMM2 using a structure-based virtual screening approach. 

    Thirumal Kumar, D; Jain, Nikita; S, Udhaya Kumar; GeorgePriya Doss, C; Zayed, Hatem ( Taylor & Francis , 2019 , Article)
    The autosomal recessive phosphomannomutase 2-congenital disorder of glycosylation (PMM2-CDG) is characterized by defective functioning of the PMM2 enzyme, which is necessary for the conversion of mannose-6-phosphate into ...
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    An extensive computational approach to analyze and characterize the functional mutations in the galactose-1-phosphate uridyl transferase (GALT) protein responsible for classical galactosemia 

    S, Udhaya Kumar; D, Thirumal Kumar; R, Siva; C, George Priya Doss; Zayed, Hatem ( Elsevier , 2019 , Article)
    Type I galactosemia is a very rare autosomal recessive genetic metabolic disorder that occurs because of the mutations present in the galactose-1-phosphate uridyl transferase (GALT) gene, resulting in a deficiency of the ...
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    Genetic Epidemiology of Hearing Loss in the 22 Arab Countries: A Systematic Review 

    Sidenna, Mariem; Fadl, Tasnim; Zayed, Hatem ( Wolters Kluwer Health , 2019 , Article)
    Hearing loss (HL) is a heterogeneous condition that causes partial or complete hearing impairment. Hundreds of variants in more than 60 genes have been reported to be associated with Hereditary HL (HHL). The HHL prevalence ...
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    miR-20b, miR-296, and Let-7f Expression in Human Adipose Tissue is Related to Obesity and Type 2 Diabetes. 

    Gentile, Adriana-Mariel; Lhamyani, Said; Coín-Aragüez, Leticia; Clemente-Postigo, Mercedes; Oliva Olivera, Wilfredo; Romero-Zerbo, Silvana-Yanina; García-Serrano, Sara; García-Escobar, Eva; Zayed, Hatem; Doblado, Esther; Bermúdez-Silva, Francisco-Javier; Murri, Mora; Tinahones, Francisco J; El Bekay, Rajaa... more authors ... less authors ( Wiley , 2019 , Article)
    This study aimed to analyze the potential association of different microRNA (miRNA) molecules with both type 2 diabetes (T2D) and obesity and determine their target genes. Quantitative PCR was used to analyze the miR-20b, ...
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    Implication of salt stress induces changes in pigment production, antioxidant enzyme activity, and qRT-PCR expression of genes involved in the biosynthetic pathway of Bixa orellana L. 

    Sankari, M; Hridya, H; Sneha, P; Doss, C George Priya; Christopher, J Godwin; Mathew, Jill; Zayed, Hatem; Ramamoorthy, Siva... more authors ... less authors ( Springer Verlag , 2019 , Article)
    The effect of salt stress on pigment synthesis and antioxidant enzyme activity as well as in the genes involved in the biosynthetic pathway of bixin was studied. The 14-day germinated seedlings of Bixa orellana were induced ...
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    • Zayed, Hatem (21)
    • George Priya Doss, C (5) Thirumal Kumar, D (5) n 2009210819 (4) ... View More
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