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AuthorGanji, Vijay
AuthorSukik, Layan
AuthorHoque, Bushra
AuthorBoutefnouchet, Linda
AuthorShi, Zumin
Available date2022-06-12T07:04:23Z
Publication Date2022-06-09
Publication NameJournal of Personalized Medicine
Identifierhttp://dx.doi.org/10.3390/jpm12060944
CitationGanji, V.; Sukik, L.; Hoque, B.; Boutefnouchet, L.; Shi, Z. Association of Serum 25-Hydroxyvitamin D Concentration with Breast Cancer Risk in Postmenopausal Women in the US. J. Pers. Med. 2022, 12, 944. https://doi.org/10.3390/jpm12060944
URIhttp://hdl.handle.net/10576/32068
AbstractThe association between serum 25-hydroxyvitamin D [25(OH)D] concentration and breast cancer risk in postmenopausal women is not well understood. The aim of this study was to investigate the association between serum 25(OH)D concentration and breast cancer in postmenopausal women in the United States using nationally representative sample surveys. We used the data from seven cycles of National Health and Nutrition Examination Surveys from 2001 to 2014. Participants were non-institutionalized postmenopausal women (n = 8108). In restricted cubic spline analysis, a significant, nonlinear, invert ‘U’ relationship was observed between serum 25(OH)D concentrations and breast cancer in postmenopausal women (p = 0.029). Overall, breast cancer risk was highest (OR = 1.5) between 70 nmol/L and 80 nmol/L of serum 25(OH)D concentration. Then after serum 25(OH)D 80 nmol/L concentration, the breast cancer risk declined. In multivariate-adjusted logistic regression, the risk of having breast cancer was significantly higher in serum 25(OH)D 75–<100 nmol/L category compared to the 25(OH)D < 30 nmol/L category [OR and 95% CI: 2.4 (1.4–4.0)]. In conclusion, serum vitamin D concentrations ≥ 100 nmol/L are associated with reduced risk of breast cancer in postmenopausal women. Controlled trials are required to verify if serum 25(OH)D ≥ 100 nmol/L offers protection against breast cancer in postmenopausal women.
SponsorQatar University, QU Health
Languageen
PublisherMDPI
Subjectbreast cancer
Subjectcancer
SubjectNHANES
SubjectNational Health and Nutrition Examination Survey
Subjectpostmenopausal women
Subjectserum 25(OH)D
SubjectUnited States
Subjectvitamin D
TitleAssociation of Serum 25-Hydroxyvitamin D Concentration with Breast Cancer Risk in Postmenopausal Women in the US
TypeArticle
Issue Number6
Volume Number12
ESSN2075-4426


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