• English
    • العربية
  • العربية
  • Login
  • QU
  • QU Library
  •  Home
  • Communities & Collections
  • Help
    • Item Submission
    • Publisher policies
    • User guides
    • FAQs
  • About QSpace
    • Vision & Mission
    • QSpace policies
View Item 
  •   Qatar University Digital Hub
  • Qatar University Institutional Repository
  • Academic
  • Student Thesis & Dissertations
  • College of Arts & Sciences
  • Biological & Environmental Sciences
  • View Item
  • Qatar University Digital Hub
  • Qatar University Institutional Repository
  • Academic
  • Student Thesis & Dissertations
  • College of Arts & Sciences
  • Biological & Environmental Sciences
  • View Item
  •      
  •  
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    EFFECT OF BIOINSPIRED SYNTHETIC ANTI-MICROBIAL PEPTIDES ON COLORECTAL CANCER CELLS (SW620)

    Thumbnail
    View/Open
    Sheema Ali Hashem_OGS Approved Thesis.pdf (2.172Mb)
    Date
    06-2022
    Author
    HASHEM, SHEEMA
    Metadata
    Show full item record
    Abstract
    Colorectal cancer (CRC) is the world's third most common cancer and the second biggest cause of cancer-related deaths. Despite significant advances in CRC therapeutic intervention, cytotoxicity, drug resistance, and adverse effects remain a major issue to be major problems, necessitating the urgent development of novel therapeutic agents. The use of Bioinspired Short Anti-Microbial Peptides (BSAMPs) as anticancer peptides could pave the way for the development of innovative anticancer treatments with better therapeutic characteristics. Anti-microbial peptides (AMPs) are a class of small peptides that widely exist in nature, and they are an essential part of the innate immune system of different organisms. AMPs have a wide range of inhibitory effects against bacteria, fungi, parasites, viruses, and even cancer cells. This study investigated the anticancer and anti-inflammatory role of novel BSAMPs in human colorectal cancer cells (SW620). The results demonstrated that BSAMPS inhibited the proliferation of CRC cells by inducing apoptosis through the activation of the intrinsic mitochondrial pathway. Moreover, treatment with BSAMPs downregulated the activation of STAT3, EGFR, Akt, and NF-kB, followed by decreased expression of c-Myc and ?-catenin. This is the first time, that BSAMPs structurally derived from naturally occurring AMPs have been recognized for their anticancer potential. These pleiotropic effects of BSAMPs on apoptosis, cell proliferation, survival, differentiation, and inflammation highlight their role as an alternative therapy in cancer treatment.
    DOI/handle
    http://hdl.handle.net/10576/32132
    Collections
    • Biological & Environmental Sciences [‎82‎ items ]

    entitlement


    Qatar University Digital Hub is a digital collection operated and maintained by the Qatar University Library and supported by the ITS department

    Contact Us | Send Feedback
    Contact Us | Send Feedback | QU

     

     

    Home

    Submit your QU affiliated work

    Browse

    All of Digital Hub
      Communities & Collections Publication Date Author Title Subject Type Language Publisher
    This Collection
      Publication Date Author Title Subject Type Language Publisher

    My Account

    Login

    Statistics

    View Usage Statistics

    About QSpace

    Vision & Mission QSpace policies

    Help

    Item Submission Publisher policiesUser guides FAQs

    Qatar University Digital Hub is a digital collection operated and maintained by the Qatar University Library and supported by the ITS department

    Contact Us | Send Feedback
    Contact Us | Send Feedback | QU

     

     

    Video