Browsing Pharmacy Research by Author "Alkilany, Alaaldin M."
Now showing items 1-7 of 7
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Can we use normal saline stored under stress conditions? A simulated prehospital emergency medical setting
Rachid, Ousama; Akkbik, Mohammed; Alkilany, Alaaldin M.; Makhlouf, Ahmed; Al Shaikh, Loua; Alinier, Guillaume... more authors ... less authors ( Elsevier Ltd , 2023 , Article)Background: Data on stability and suitability to use normal saline stored under stress conditions in ambulances is lacking. Objective: We aimed to study the impact of exposure to extreme temperature variations on normal ... -
Comprehensive evaluation of the pharmacological and toxicological effects of γ-valerolactone as compared to γ-hydroxybutyric acid: Insights from in vivo and in silico models
Arfè, Raffaella; Bilel, Sabrine; Tirri, Micaela; Corli, Giorgia; Bergamin, Eva; Serpelloni, Giovanni; Bassi, Marta; Borsari, Martina; Boccuto, Federica; Bernardi, Tatiana; Caruso, Lorenzo; Alkilany, Alaaldin M.; Rachid, Ousama; Botrè, Francesco; De-Giorgio, Fabio; Marti, Matteo... more authors ... less authors ( Elsevier , 2023 , Article)Γ-valerolactone (GVL), marketed online as “Tranquilli-G” and “excellent Valium”, is used as a legal substitute for γ-hydroxybutyric acid (GHB); however, until now, GVL has only been connected to one Drug-Facilitated Sexual ... -
Doxorubicin conjugates: a practical approach for its cardiotoxicity alleviation
Ibrahim, Abed Alqader; Nsairat, Hamdi; Al-Sulaibi, Mazen; El-Tanani, Mohamed; Jaber, Areej M.; Lafi, Zainab; Barakat, Rahmeh; Abuarqoub, Duaa Azmi; Mahmoud, Ismail Sami; Obare, Sherine O.; Aljabali, Alaa A.A.; Alkilany, Alaaldin M.; Alshaer, Walhan... more authors ... less authors ( Taylor & Francis , 2024 , Article)Introduction: Doxorubicin (DOX) emerges as a cornerstone in the arsenal of potent chemotherapeutic agents. Yet, the clinical deployment of DOX is tarnished by its proclivity to induce severe cardiotoxic effects, culminating ... -
Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer
El-Tanani, Mohamed; Nsairat, Hamdi; Aljabali, Alaa A.; Matalka, Ismail I.; Alkilany, Alaaldin M.; Tambuwala, Murtaza M.... more authors ... less authors ( Taylor & Francis , 2024 , Article)Introduction: The resistance to chemotherapy is a significant hurdle in breast cancer treatment, prompting the exploration of innovative strategies. This review discusses the potential of dual-loaded liposomal carriers to ... -
Eutectics in Pharmacy Curriculum: A Simple Demonstration with Pharmaceutical Relevance
Daou, Anis; Arakkal, Shijimol M.; Alkilany, Alaaldin M. ( acs Publications , 2023 , Article)In chemistry, a eutectic mixture refers to a mixture of two or more components at which the lowest possible freezing point is observed. This phenomenon is covered in a wide range of curricula such as physics, chemistry, ... -
Quality by Design Approach in Liposomal Formulations: Robust Product Development
Alshaer, Walhan; Nsairat, Hamdi; Lafi, Zainab; Hourani, Omar M.; Al-Kadash, Abdulfattah; Esawi, Ezaldeen; Alkilany, Alaaldin M.... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Nanomedicine is an emerging field with continuous growth and differentiation. Liposomal formulations are a major platform in nanomedicine, with more than fifteen FDA-approved liposomal products in the market. However, as ... -
The synthetic cathinones MDPHP and MDPV: Comparison of the acute effects in mice, in silico ADMET profiles and clinical reports
Marta, Bassi; Bilel, Sabrine; Tirri, Micaela; Corli, Giorgia; Di Rosa, Fabiana; Gregori, Adolfo; Alkilany, Alaaldin M.; Rachid, Ousama; Roda, Elisa; De Luca, Fabrizio; Papa, Pietro; Buscaglia, Eleonora; Zauli, Giorgio; Locatelli, Carlo Alessandro; Marti, Matteo... more authors ... less authors ( Elsevier , 2024 , Article)The 3,4-methylenedioxy-alpha-pyrrolidinohexanophenone (MDPHP) is a synthetic cathinone closely related to 3,4-methylenedioxypyrovalerone (MDPV), one of the most common synthetic cathinones present in the “bath salts”. MDPHP ...