Browsing Pharmacy Research by Subject "pharmacokinetics"
Now showing items 1-8 of 8
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Creation of an inventory of quality markers used to evaluate pharmacokinetic literature: A systematic review
( Wiley , 2021 , Article Review)What is known and objective: Robust critical appraisal tools for clinical pharmacokinetic studies are limited. Before development of such a tool is possible, quality markers (items deemed important for credibility of study ... -
Effect of hyperlipidemia on ketoconazole-midazolam drug-drug interaction in rat
( John Wiley & Sons, Ltd. , 2011 , Article)Hyperlipidemia (HL) was previously shown to lower liver uptake of the more potent (-) enantiomer of ketoconazole (KTZ) in rat. The current study examined the possible modifying influence of experimental HL on a KTZ ... -
Effect of rat serum lipoproteins on mRNA levels and amiodarone metabolism by cultured primary rat hepatocytes
( Wiley Periodicals, Inc. , 2013 , Article)Hyperlipidemia can significantly increase amiodarone (AM) in vivo liver uptake and decrease its velocity of microsomal metabolism. Here, hepatocytes isolated from normolipidemic (NL) and hyperlipidemic rats were incubated ... -
Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes
( John Wiley & Sons, Ltd , 2012 , Article)Experimental hyperlipidemia has shown to decrease cytochrome P450 3A4 and 2C11 expression and to increase liver concentrations and the plasma protein binding of halofantrine (HF) enantiomers. The present study examined the ... -
Interleukin-2: Evaluation of routes of administration and current delivery systems in cancer therapy
( Wiley Subscription Services, Inc., A Wiley Company , 2009 , Article)Despite the fact that different administration routes and delivery systems have been used for interleukin-2 (IL-2) delivery, little has been reported regarding the most efficient strategies used to deliver IL-2 in a nontoxic, ... -
Pharmacokinetics and tissue distribution of an orally administered mucoadhesive chitosan-coated amphotericin B-Loaded nanostructured lipid carrier (NLC) in rats
( Taylor and Francis Inc. , 2020 , Article)Oral delivery of amphotericin B (AmpB) is desirable because it provides a more patient-friendly mode of administration compared to the current delivery approach akin with the marketed AmpB formulations. The goal of the ... -
Pharmacokinetics, Pharmacodynamics, and Dosing Considerations of Novel β-Lactams and β-Lactam/β-Lactamase Inhibitors in Critically Ill Adult Patients: Focus on Obesity, Augmented Renal Clearance, Renal Replacement Therapies, and Extracorporeal Membrane Oxygenation
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Objective: Dose optimization of novel β-lactam antibiotics (NBLA) has become necessary given the increased prevalence of multidrug-resistant infections in intensive care units coupled with the limited number of available ... -
Vancomycin therapeutic drug monitoring service quality indices and clinical effectiveness outcomes: A retrospective cohort and clinical audit
( Blackwell Publishing Ltd , 2020 , Article)Introduction: Vancomycin is commonly used for the treatment of complicated infections caused by methicillin-resistant Staphylococcus aureus. The impact of vancomycin therapeutic drug monitoring (TDM) quality indices on ...