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Effect of hyperlipidemia on ketoconazole-midazolam drug-drug interaction in rat
(
John Wiley & Sons, Ltd.
, 2011 , Article)
Hyperlipidemia (HL) was previously shown to lower liver uptake of the more potent (-) enantiomer of ketoconazole (KTZ) in rat. The current study examined the possible modifying influence of experimental HL on a KTZ ...
Effect of rat serum lipoproteins on mRNA levels and amiodarone metabolism by cultured primary rat hepatocytes
(
Wiley Periodicals, Inc.
, 2013 , Article)
Hyperlipidemia can significantly increase amiodarone (AM) in vivo liver uptake and decrease its velocity of microsomal metabolism. Here, hepatocytes isolated from normolipidemic (NL) and hyperlipidemic rats were incubated ...
Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes
(
John Wiley & Sons, Ltd
, 2012 , Article)
Experimental hyperlipidemia has shown to decrease cytochrome P450 3A4 and 2C11 expression and to increase liver concentrations and the plasma protein binding of halofantrine (HF) enantiomers. The present study examined the ...