Browsing Mechanical & Industrial Engineering by Author "Caceci T."
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Current progress in chimeric antigen receptor T cell therapy for glioblastoma multiforme
Marei H.E.; Althani A.; Afifi N.; Hasan, Anwarul; Caceci T.; Pozzoli G.; Cenciarelli C.... more authors ... less authors ( John Wiley and Sons Inc , 2021 , Article)Glioblastoma multiforme (GBM) is one of the deadliest brain tumors with an unfavorable prognosis and overall survival of approximately 20 months following diagnosis. The current treatment for GBM includes surgical resections ... -
Exome sequencing of glioblastoma-derived cancer stem cells reveals rare clinically relevant frameshift deletion in MLLT1 gene
Marei H.E.; Althani A.; Afifi N.; Hasan, Anwarul; Caceci T.; Felsani A.; Tringali G.; Cifola I.; Pozzoli G.; Cenciarelli C.... more authors ... less authors ( BioMed Central Ltd , 2022 , Article)Background: Glioblastoma multiforme (GBM) is a heterogeneous CNS neoplasm which causes significant morbidity and mortality. One reason for the poor prognostic outcome of GBM is attributed to the presence of cancer stem ... -
Generation of gene edited hiPSC from familial Alzheimer's disease patient carrying N141I missense mutation in presenilin 2
Marei H.E.; Althani A.; Afifi N.; Hasan, Anwarul; Caceci T.; Pozzoli G.; Cenciarelli C.... more authors ... less authors ( Elsevier B.V. , 2021 , Article)Alzheimer's disease (AD) is the major cause of dementia worldwide. Early-onset familial AD accounts for about 0.5% of all AD and is caused by single major gene mutations and autosomal dominant inheritance. An N141I missense ... -
p53 signaling in cancer progression and therapy
Marei H.E.; Althani A.; Afifi N.; Hasan, Anwarul; Caceci T.; Pozzoli G.; Morrione A.; Giordano A.; Cenciarelli C.... more authors ... less authors ( BioMed Central Ltd , 2021 , Article)The p53 protein is a transcription factor known as the "guardian of the genome" because of its critical function in preserving genomic integrity. The TP53 gene is mutated in approximately half of all human malignancies, ...