Browsing Mechanical & Industrial Engineering by Publisher "BioMed Central Ltd"
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Cancer immunotherapy with immune checkpoint inhibitors (ICIs): potential, mechanisms of resistance, and strategies for reinvigorating T cell responsiveness when resistance is acquired
( BioMed Central Ltd , 2023 , Article Review)Cancer is still the leading cause of death globally. The approval of the therapeutic use of monoclonal antibodies against immune checkpoint molecules, notably those that target the proteins PD-1 and PD-L1, has changed the ... -
Current status and innovative developments of CAR-T-cell therapy for the treatment of breast cancer
( BioMed Central Ltd , 2025 , Article Review)Breast cancer will overtake all other cancers in terms of diagnoses in 2024. Breast cancer counts highest among women in terms of cancer incidence and death rates. Innovative treatment approaches are desperately needed ... -
Exome sequencing of glioblastoma-derived cancer stem cells reveals rare clinically relevant frameshift deletion in MLLT1 gene
( BioMed Central Ltd , 2022 , Article)Background: Glioblastoma multiforme (GBM) is a heterogeneous CNS neoplasm which causes significant morbidity and mortality. One reason for the poor prognostic outcome of GBM is attributed to the presence of cancer stem ... -
p53 signaling in cancer progression and therapy
( BioMed Central Ltd , 2021 , Article)The p53 protein is a transcription factor known as the "guardian of the genome" because of its critical function in preserving genomic integrity. The TP53 gene is mutated in approximately half of all human malignancies, ... -
Potential of antibody-drug conjugates (ADCs) for cancer therapy
( BioMed Central Ltd , 2022 , Article Review)The primary purpose of ADCs is to increase the efficacy of anticancer medications by minimizing systemic drug distribution and targeting specific cells. Antibody conjugates (ADCs) have changed the way cancer is treated. ...
