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المؤلفPaul, A.
المؤلفPaul, Alapan
المؤلفAugustine, Robin
المؤلفHasan, Anwarul
المؤلفZahid, Alap Ali
المؤلفThomas, Sabu
المؤلفAgatemor, Christian
المؤلفGhosal, Kajal
تاريخ الإتاحة2022-09-11T08:24:39Z
تاريخ النشر2022-06-01
اسم المنشورJournal of Drug Delivery Science and Technology
المعرّفhttp://dx.doi.org/10.1016/j.jddst.2022.103380
الاقتباسPaul, A., Augustine, R., Hasan, A., Zahid, A. A., Thomas, S., Agatemor, C., & Ghosal, K. (2022). Halloysite nanotube and chitosan polymer composites: Physicochemical and drug delivery properties. Journal of Drug Delivery Science and Technology, 72, 103380.‏
الرقم المعياري الدولي للكتاب17732247
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85129771673&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/33806
الملخصAdvancement in healthcare requires sophisticated and safe drug delivery systems. An ideal drug delivering system should be non-toxic, therapeutically inert, and be able to deliver a wide range of drugs. Here, we report halloysite nanotubes (HNTs) and its nanocomposite with chitosan for the delivery of diclofenac. The nanomaterials were characterized using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM). Also, water absorption studies, cytotoxicity studies, and in vitro diffusion studies were carried out to ascertain the behaviour of the nanomaterials. SEM confirmed tubular morphology of HNTs and suggest drug loading within nanotubes. Further, XRD diffraction patterns of diclofenac and HNTs in drug-loaded nanotubes and composites confirmed loading of drug in nanotubes at the first step of processing and encapsulation within composites in subsequent step. FTIR showed very few drug bands within drug loaded nanotubes and composite, confirming encapsulation of the drug. Nanocomposite films were found to sustain drug release for a longer duration. The drug sustaining phenomenon was confirmed via in vitro diffusion studies and water absorption studies. Cytotoxicity study performed by MTT assay suggests biocompatibility of HNTs nanomaterials. Overall, the studies imply that HNTs could be exploited as a biocompatible nanomaterials to deliver drugs that demand sustained therapeutic action.
اللغةen
الناشرEditions de Sante
الموضوعBiocompatible
Cationic drug
Encapsulation
Halloysite nanotubes
Nanovehicle
العنوانHalloysite nanotube and chitosan polymer composites: Physicochemical and drug delivery properties
النوعArticle
رقم المجلد72
dc.accessType Abstract Only


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