Browsing Research Units by Author "Cyprian, Farhan S."
Now showing items 1-7 of 7
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Antibody-Dependent Enhancement (ADE) and the role of complement system in disease pathogenesis
Thomas, Swapna; Smatti, Maria K.; Ouhtit, Allal; Cyprian, Farhan S.; Almaslamani, Muna A.; Al Thani, Asmaa; Yassine, Hadi M.... more authors ... less authors ( Elsevier Ltd , 2022 , Article Review)Antibody-dependent enhancement (ADE) has been associated with severe disease outcomes in several viral infections, including respiratory infections. In vitro and in vivo studies showed that antibody-response to SARS-CoV ... -
Design, synthesis, and validation of novel nitrogen-based chalcone analogs against triple negative breast cancer
Elkhalifa, Dana; Siddique, Abu Bakar; Qusa, Mohammed; Cyprian, Farhan S.; El Sayed, Khalid; Alali, Feras; Al Moustafa, Ala-Eddin; Khalil, Ashraf... more authors ... less authors ( Elsevier Masson s.r.l. , 2020 , Article)Great strides have been made in triple negative breast cancer (TNBC) treatment, which represents 20% of total predicted annual US breast cancer (BC) cases. Despite the development of several therapeutics, TNBC patients ... -
Detection of Antinuclear Antibodies Targeting Intracellular Signal Transduction, Metabolism, Apoptotic Processes and Cell Death in Critical COVID-19 Patients
Nasarallah, Gheyath K.; Fakhroo, Aisha D.; Khan, Taushif; Cyprian, Farhan S.; Al Ali, Fatima; Ata, Manar M.A.; Taleb, Sara; Zedan, Hadeel T.; Al-Sadeq, Duaa W.; Amanullah, Fathima H.; Hssain, Ali A.; Eid, Ali H.; Abu-Raddad, Laith J.; Al-Khal, Abdullatif; Al Thani, Asmaa A.; Marr, Nico; Yassine, Hadi M.... more authors ... less authors ( Universita Cattolica del Sacro Cuore , 2022 , Article)Background and Objectives: The heterogeneity of the coronavirus disease of 2019 (COVID-19) lies within its diverse symptoms and severity, ranging from mild to lethal. Acute respiratory distress syndrome (ARDS) is a leading ... -
High-risk human papillomaviruses and epstein-barr virus presence and crosstalk in human oral carcinogenesis
Al Moustafa, Ala Eddin; Cyprian, Farhan S.; Al-Antary, Noor; Yasmeen, Amber ( Springer International Publishing , 2017 , Book chapter)Oral cancer is the most frequent type of malignancy of the head and neck area worldwide. This cancer is a major cause of mortality in several parts of the world especially in certain Asian countries. In fact, the majority ... -
Immunomodulation Induced by Host Pathogen Interaction
Yassine, Hadi M.; Moin, Syed M.; Cyprian, Farhan S.; Wheatley, Adam K.; Nasrallah, Gheyath K. ( Hindawi , 2019 , Article)Controlling and preventing infections require deep understanding of the complex interplay that occurs between the host and pathogen following infection. In essence, immunomodulation is any process leading to an immune ... -
The retrospective study of the metabolic patterns of BCG-vaccination in type-2 diabetic individuals in COVID-19 infection
Anwardeen, Najeha R.; Cyprian, Farhan S.; Yassine, Hadi M.; Al-Thani, Asmaa A.; Abdallah, Abdallah M.; Emara, Mohamed M.; Elrayess, Mohamed A.... more authors ... less authors ( Frontiers Media , 2023 , Article)Background: The cross-protective nature of Bacillus Calmette-Guerin (BCG) vaccine against SARS-CoV-2 virus was previously suggested, however its effect in COVID-19 patients with type 2 diabetes (T2D) and the underlying ... -
Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways
Hadeel, Kheraldine; Gupta, Ishita; Alhussain, Hashim; Jabeen, Aayesha; Cyprian, Farhan S.; Akhtar, Saghir; Al Moustafa, Ala-Eddin; Rachid, Ousama... more authors ... less authors ( Elsevier , 2021 , Article)HER2-positive breast cancer is one of its most challenging subtypes, forming around 15–25% of the total cases. It is characterized by aggressive behavior and treatment resistance. On the other hand, poly (amidoamine) (PAMAM) ...