Browsing Research Units by Author "Alali,Feras"
Now showing items 1-4 of 4
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Design, synthesis, and validation of novel nitrogen-based chalcone analogs against triple negative breast cancer
Elkhalifa, Dana; Siddique, Abu Bakar; Qusa, Mohammed; Cyprian, Farhan S.; El Sayed, Khalid; Alali, Feras; Al Moustafa, Ala-Eddin; Khalil, Ashraf... more authors ... less authors ( Elsevier Masson s.r.l. , 2020 , Article)Great strides have been made in triple negative breast cancer (TNBC) treatment, which represents 20% of total predicted annual US breast cancer (BC) cases. Despite the development of several therapeutics, TNBC patients ... -
Development of Novel Chalcone Analogs as Potential Multi-Targeted Therapies for Castration-Resistant Prostate Cancer
Hussein, Ola; Alali, Feras; Al Mustafa, Ala?Eddin; Khalil, Ashraf ( Qatar University Press , 2021 , Poster)Prostate cancer (PCa) is the second most frequently diagnosed malignancy, as well as a leading cause of cancer-related mortality in men globally. Despite the initial response to hormonal targeted therapy, the majority of ... -
Novel polymethoxylated chalcones as potential compounds against kras-mutant colorectal cancers
Mahmoud, Alaa; Elkhalifa, Dana; Alali, Feras; Al Moustafa, Ala-Eddin; Khalil, Ashraf ( Bentham Science Publishers , 2020 , Article)Background/Objective: KRAS-mutant colorectal cancers (CRC) are tumors that are associated with poor prognosis. However, no effective treatments are available to target them. Therefore, we designed and synthesized novel ... -
Targeting triple negative breast cancer heterogeneity with chalcones: a molecular insight.
Elkhalifa, Dana; Alali, Feras; Al Moustafa, Ala-Eddin; Khalil, Ashraf ( Informa Healthcare , 2019 , Article Review)Triple negative breast cancers (TNBCs) are aggressive heterogeneous cancers with not yet determined conventional targeted medication. Therefore, identification of new alternatives or improved treatment options to combat ...