تصفح Research Units حسب المؤلف "Fakhro, Khalid A."
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Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model
Da'as, Sahar I.; Yalcin, Huseyin C.; Nasrallah, Gheyath K.; Mohamed, Iman A.; Nomikos, Michail; Yacoub, Magdi H.; Fakhro, Khalid A.... more authors ... less authors ( Wiley , 2020 , Article)© 2020 Wiley Periodicals, Inc. Myosin-binding protein C 3 (MYBPC3) variants are the most common cause of hypertrophic cardiomyopathy (HCM). HCM is a complex cardiac disorder due to its significant genetic and clinical ... -
The QChip1 knowledgebase and microarray for precision medicine in Qatar
Rodriguez-Flores, Juan L.; Messai-Badji, Radja; Robay, Amal; Temanni, Ramzi; Syed, Najeeb; Markovic, Monika; Al-khayat, Eiman; Qafoud, Fatima; Nawaz, Zafar; Badii, Ramin; Al-Sarraj, Yasser; Mbarek, Hamdi; Al-Muftah, Wadha; Alvi, Muhammad; Rostami, Mahboubeh R.; Cruzado, Juan Carlos Martinez; Mezey, Jason G.; Shakaki, Alya Al; Malek, Joel A.; Greenblatt, Matthew B.; Fakhro, Khalid A.; Machaca, Khaled; Al-Nabet, Ajayeb; Afifi, Nahla; Brooks, Andrew; Ismail, Said I.; Althani, Asmaa; Crystal, Ronald G.... more authors ... less authors ( Nature Research , 2022 , Article)Risk genes for Mendelian (single-gene) disorders (SGDs) are consistent across populations, but pathogenic risk variants that cause SGDs are typically population-private. The goal was to develop "QChip1," an inexpensive ... -
Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model
Da’as, Sahar Isa; Hasan, Waseem; Salem, Rola; Younes, Nadine; Abdelrahman, Doua; Mohamed, Iman A.; Aldaalis, Arwa; Temanni, Ramzi; Mathew, Lisa Sara; Lorenz, Stephan; Yacoub, Magdi; Nomikos, Michail; Nasrallah, Gheyath K.; Fakhro, Khalid A.... more authors ... less authors ( MDPI , 2022 , Article)Variants in cardiac myosin-binding protein C (cMyBP-C) are the leading cause of inherited hypertrophic cardiomyopathy (HCM), demonstrating the key role that cMyBP-C plays in the heart’s contractile machinery. To investigate ...